Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 5406457..5407091 Replicon chromosome
Accession NZ_CP023956
Organism Serratia fonticola strain FDAARGOS_411

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CRN79_RS24535 Protein ID WP_098931989.1
Coordinates 5406915..5407091 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CRN79_RS24530 Protein ID WP_098931338.1
Coordinates 5406457..5406864 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN79_RS24490 5402707..5403243 - 537 WP_098931330.1 DUF2280 domain-containing protein -
CRN79_RS24495 5403275..5403892 - 618 WP_098931331.1 hypothetical protein -
CRN79_RS24500 5404319..5404696 - 378 WP_098931332.1 hypothetical protein -
CRN79_RS24510 5404970..5405329 - 360 WP_098931334.1 DUF2570 family protein -
CRN79_RS24515 5405326..5405718 - 393 WP_098931335.1 M15 family metallopeptidase -
CRN79_RS24520 5405715..5406002 - 288 WP_098931336.1 phage holin family protein -
CRN79_RS24525 5405995..5406363 - 369 WP_098931337.1 hypothetical protein -
CRN79_RS24530 5406457..5406864 - 408 WP_098931338.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CRN79_RS24535 5406915..5407091 - 177 WP_098931989.1 type II toxin-antitoxin system HicA family toxin Toxin
CRN79_RS24540 5407173..5407895 - 723 WP_098931339.1 protein mom -
CRN79_RS24545 5408110..5408931 - 822 WP_098931340.1 antitermination protein -
CRN79_RS24550 5408928..5409284 - 357 WP_098931341.1 RusA family crossover junction endodeoxyribonuclease -
CRN79_RS24555 5409281..5409703 - 423 WP_098931342.1 hypothetical protein -
CRN79_RS24560 5409703..5411106 - 1404 WP_098931343.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5355098..5425560 70462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-61)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6679.84 Da        Isoelectric Point: 11.1683

>T86442 WP_098931989.1 NZ_CP023956:c5407091-5406915 [Serratia fonticola]
VKQREFQRWLAAQGAEFSNGTNHLKIYLNGKQTIMPRHPGKEIPEPLRKAILKQLGLK

Download         Length: 177 bp

>T86442 NZ_CP023956:c5407091-5406915 [Serratia fonticola]
GTGAAGCAACGCGAGTTTCAGCGTTGGCTTGCAGCACAAGGGGCGGAGTTTTCAAACGGTACCAACCACCTGAAAATCTA
CCTCAACGGCAAGCAGACGATAATGCCAAGGCATCCGGGGAAGGAAATACCGGAGCCGCTGAGAAAAGCGATTCTCAAGC
AACTTGGCCTTAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14797.90 Da        Isoelectric Point: 4.5348

>AT86442 WP_098931338.1 NZ_CP023956:c5406864-5406457 [Serratia fonticola]
MRYPVKFEHDETGWCVSFPDIPEALTGGDTREEALSLAQDALVTAFDFYFEDRRPVPMPSADGEEFIDVPASVAAKVLLL
NAMIATGTTPAELARRLGTRPQEVNRIVTLNHATKIDTIEAALKALGKRLEITAL

Download         Length: 408 bp

>AT86442 NZ_CP023956:c5406864-5406457 [Serratia fonticola]
ATGCGATATCCCGTAAAATTTGAGCATGACGAAACCGGGTGGTGTGTATCGTTCCCGGATATCCCGGAGGCACTAACGGG
CGGAGATACCAGGGAAGAGGCGCTATCGTTGGCGCAAGACGCCCTGGTAACGGCGTTTGATTTTTACTTTGAAGATCGGC
GGCCCGTACCGATGCCAAGCGCTGACGGCGAAGAGTTTATCGATGTGCCAGCGAGTGTGGCGGCTAAGGTGCTGTTGCTT
AACGCCATGATCGCCACCGGCACAACACCGGCAGAACTGGCCCGCCGCCTGGGTACAAGACCGCAGGAAGTTAACCGGAT
CGTTACCCTGAACCACGCAACCAAAATCGACACGATAGAGGCTGCGCTTAAGGCGCTGGGCAAGCGGCTAGAAATAACCG
CGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References