Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3325940..3326609 Replicon chromosome
Accession NZ_CP023956
Organism Serratia fonticola strain FDAARGOS_411

Toxin (Protein)


Gene name cptA Uniprot ID A0A1C7W8D5
Locus tag CRN79_RS14900 Protein ID WP_065684482.1
Coordinates 3326187..3326609 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID U2M6Q5
Locus tag CRN79_RS14895 Protein ID WP_021179805.1
Coordinates 3325940..3326206 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN79_RS14870 3321138..3321884 + 747 WP_098929866.1 SDR family oxidoreductase -
CRN79_RS14875 3322359..3322967 - 609 WP_098929867.1 HD domain-containing protein -
CRN79_RS14880 3323204..3323878 + 675 WP_065684483.1 hemolysin III family protein -
CRN79_RS14885 3324110..3324607 + 498 WP_021179803.1 DUF2165 domain-containing protein -
CRN79_RS14890 3324647..3325639 - 993 WP_098931826.1 tRNA-modifying protein YgfZ -
CRN79_RS14895 3325940..3326206 + 267 WP_021179805.1 FAD assembly factor SdhE Antitoxin
CRN79_RS14900 3326187..3326609 + 423 WP_065684482.1 protein YgfX Toxin
CRN79_RS14905 3326609..3327304 + 696 WP_098929868.1 two-component system response regulator CreB -
CRN79_RS14910 3327301..3328719 + 1419 WP_098929869.1 two-component system sensor histidine kinase CreC -
CRN79_RS14915 3328823..3330211 + 1389 WP_098929870.1 cell envelope integrity protein CreD -
CRN79_RS14920 3330247..3330765 - 519 WP_021179810.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-78)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16510.41 Da        Isoelectric Point: 10.3439

>T86432 WP_065684482.1 NZ_CP023956:3326187-3326609 [Serratia fonticola]
VAQWRCDVRVSWRTQLVSLLTHGLLILLILIAPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRIEWHGQ
EWLMVNKPWMPGFGILLSLQQIDGKKRHRLWLASDSMSKADWRQLRQRLLFEQSATDEDV

Download         Length: 423 bp

>T86432 NZ_CP023956:3326187-3326609 [Serratia fonticola]
GTGGCCCAGTGGCGATGTGATGTCCGCGTTTCCTGGCGTACCCAGTTAGTCTCATTGCTGACTCACGGCCTGCTCATTTT
GCTGATCCTGATCGCCCCGTGGCCGGAAGGTTATGGCCCGATCTGGTTAGTGCTGTTGACGTTGGTGGTGTTTGAGTGCA
TTCGCAGCCAAAAGCGCATTGCATCCAGGCAGGGAGAACTGCGGTTGCTGGCTGAACGCCGGATTGAGTGGCATGGCCAG
GAATGGCTGATGGTGAACAAGCCCTGGATGCCTGGGTTCGGTATTTTGCTGTCGCTTCAACAGATCGATGGCAAGAAACG
CCATCGGCTGTGGTTGGCTTCGGATTCCATGAGCAAAGCGGATTGGCGTCAACTGCGTCAACGGTTGTTGTTTGAACAAT
CCGCTACCGACGAGGACGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10363.93 Da        Isoelectric Point: 5.5847

>AT86432 WP_021179805.1 NZ_CP023956:3325940-3326206 [Serratia fonticola]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDADKAVFIRLLECDDPDLFNWLMNHGAPQDQDLQRMVSLIQMRN
KARGPVAM

Download         Length: 267 bp

>AT86432 NZ_CP023956:3325940-3326206 [Serratia fonticola]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGCGGCATGCGCGAGTTGGATATCTCGATCATGCCGTT
TTTCGAACATGAATACGATACGCTGAGTGATGCAGACAAGGCCGTATTCATCCGCTTGCTCGAATGTGACGACCCCGATT
TGTTCAACTGGCTGATGAATCATGGTGCTCCGCAGGATCAAGATCTGCAGAGAATGGTGTCCCTGATCCAAATGCGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7W8D5

Antitoxin

Source ID Structure
AlphaFold DB U2M6Q5

References