Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3020103..3020656 Replicon chromosome
Accession NZ_CP023956
Organism Serratia fonticola strain FDAARGOS_411

Toxin (Protein)


Gene name ccdB Uniprot ID U2NFJ3
Locus tag CRN79_RS13570 Protein ID WP_021179490.1
Coordinates 3020103..3020417 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1C7WDQ0
Locus tag CRN79_RS13575 Protein ID WP_065684692.1
Coordinates 3020420..3020656 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN79_RS13545 3016339..3016554 - 216 WP_001144069.1 30S ribosomal protein S21 -
CRN79_RS13550 3016879..3017892 + 1014 WP_098929749.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD -
CRN79_RS13555 3017924..3018562 - 639 WP_021179487.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
CRN79_RS13560 3018670..3019029 + 360 WP_098929750.1 bifunctional dihydroneopterin aldolase/7,8-dihydroneopterin epimerase -
CRN79_RS13565 3019170..3019997 + 828 WP_065684693.1 undecaprenyl-diphosphate phosphatase -
CRN79_RS13570 3020103..3020417 - 315 WP_021179490.1 CcdB family protein Toxin
CRN79_RS13575 3020420..3020656 - 237 WP_065684692.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CRN79_RS13580 3020971..3022626 + 1656 WP_098929751.1 L-lactate permease -
CRN79_RS13585 3022623..3023405 + 783 WP_098929752.1 transcriptional regulator LldR -
CRN79_RS13590 3023422..3024561 + 1140 WP_065684689.1 FMN-dependent L-lactate dehydrogenase LldD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11579.56 Da        Isoelectric Point: 6.9725

>T86430 WP_021179490.1 NZ_CP023956:c3020417-3020103 [Serratia fonticola]
MQFTVYYNPGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSSRPDRMNPVIMLTDGKEYAVMAHELASIPVRALG
AEFCNAAQYRPQIKAAIDFLIDGI

Download         Length: 315 bp

>T86430 NZ_CP023956:c3020417-3020103 [Serratia fonticola]
ATGCAATTCACCGTCTACTACAATCCCGGAAAAAGCGTCGTTTATCCCCTGCTACTTGATGTAACGAGCGATATTATCGG
CCAGTTAAACCGTCGCATTGTGATCCCACTGTTGCCTGTTGAAAAATATCCGGGCAGCAGTCGCCCAGACCGGATGAATC
CGGTAATCATGCTGACGGACGGCAAAGAATACGCCGTAATGGCTCATGAACTTGCAAGTATTCCTGTTCGTGCTTTGGGT
GCTGAGTTCTGCAATGCGGCGCAATACCGCCCGCAGATAAAAGCGGCAATAGATTTTCTCATTGATGGAATTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8870.92 Da        Isoelectric Point: 7.3600

>AT86430 WP_065684692.1 NZ_CP023956:c3020656-3020420 [Serratia fonticola]
MTVKVRNTQSVTMTVERGLLNRARDAGINLSATLTAALDAELRHHAAKKWQEENRGALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT86430 NZ_CP023956:c3020656-3020420 [Serratia fonticola]
ATGACAGTAAAAGTACGCAATACACAAAGCGTCACAATGACTGTAGAACGAGGCCTGCTTAACCGGGCACGTGATGCAGG
AATTAACCTTAGTGCCACTTTGACTGCCGCCCTAGATGCCGAACTACGTCATCACGCAGCGAAAAAATGGCAGGAAGAAA
ACAGAGGGGCTCTTGAGGCGTTAAATCGTTTCCATGATGAACACGGCTGCTTTAGCGATGAGTACAGGACTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2NFJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7WDQ0

References