Detailed information of TA system TA086428

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 873060..873682
• Replicon: chromosome
• Accession: NZ_CP023956
• Organism: Serratia fonticola strain FDAARGOS_411

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: U2M374
• Locus tag: CRN79_RS03880
• Protein ID: WP_021180142.1
• Coordinates: 873479..873682 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: U2NAN4
• Locus tag: CRN79_RS03875
• Protein ID: WP_021180141.1
• Coordinates: 873060..873428 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRN79_RS03845	869199..869456	+	258	WP_024528397.1	type B 50S ribosomal protein L31	-
CRN79_RS03850	869469..869609	+	141	WP_021805462.1	type B 50S ribosomal protein L36	-
CRN79_RS03855	869717..870595	-	879	WP_098928402.1	zinc ABC transporter substrate-binding protein	-
CRN79_RS03860	870620..871477	-	858	WP_065686281.1	metal ABC transporter permease	-
CRN79_RS03865	871477..872169	-	693	WP_098931715.1	ABC transporter ATP-binding protein	-
CRN79_RS03870	872549..872902	+	354	WP_098931717.1	hypothetical protein	-
CRN79_RS03875	873060..873428	+	369	WP_021180141.1	Hha toxicity modulator TomB	Antitoxin
CRN79_RS03880	873479..873682	+	204	WP_021180142.1	hemolysin expression modulator Hha	Toxin
CRN79_RS03885	873765..874691	-	927	WP_098928404.1	LysR family transcriptional regulator	-
CRN79_RS03890	874828..876615	+	1788	WP_098928406.1	adenine deaminase	-
CRN79_RS03900	876996..877310	+	315	WP_098928407.1	MGMT family protein	-
CRN79_RS03905	877364..877852	-	489	WP_024484390.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8099.48 Da
• Isoelectric Point: 6.9770

>T86428 WP_021180142.1 NZ_CP023956:873479-873682 [Serratia fonticola]
MTKIDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Nucleotide

• Length: 204 bp

>T86428 NZ_CP023956:873479-873682 [Serratia fonticola]
ATGACAAAAATTGACTATCTGATGCGTTTGCGTAAATGCACCACGATTGAAACCCTTGAGCGCGTGATTGAGAAAAATAA
GTACGAACTCTCTGACGATGAGCTAGAGCTGTTCTACTCTGCTGCCGATCATCGCCTGGCCGAACTGACCATGAACAAGC
TGTACGATAAAATTCCGGTCGCCGTTTGGAAATTTGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14097.78 Da
• Isoelectric Point: 4.5140

>AT86428 WP_021180141.1 NZ_CP023956:873060-873428 [Serratia fonticola]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYMDEGDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARTFRLFSGEGVCTTMKT

Nucleotide

• Length: 369 bp

>AT86428 NZ_CP023956:873060-873428 [Serratia fonticola]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAACTCAAATTCTTATGTGAAAATTTGTACGACGAAGGCATCGC
TACCTTGGGTGACAGCCACCACGGCTGGGTTAACGATCCAACGTCCGCCGTCAATCTGCAGCTTAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTAATGAGTTTTAAAATTAAATACATGGACGAAGGTGATTTATCGGAACTGGTCGAAGAGTACCTC
GACGATACCTACACACTGTTTAGCAGCTACGGTATTAATGACTCCGATTTGCGTCGCTGGCAAAAAACCAAGGCGCGCAC
ATTCAGATTGTTCTCAGGAGAGGGCGTCTGTACCACGATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: U2M374

Antitoxin

• AlphaFold DB: U2NAN4