Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3693822..3694338 Replicon chromosome
Accession NZ_CP023913
Organism Klebsiella pneumoniae strain FDAARGOS_439

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag CRN23_RS18275 Protein ID WP_009486548.1
Coordinates 3693822..3694106 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CRN23_RS18280 Protein ID WP_002886901.1
Coordinates 3694096..3694338 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN23_RS18255 3689239..3689547 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
CRN23_RS30095 3689632..3689805 + 174 WP_032433782.1 hypothetical protein -
CRN23_RS18260 3689808..3690551 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CRN23_RS18265 3690908..3693046 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CRN23_RS18270 3693354..3693818 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CRN23_RS18275 3693822..3694106 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CRN23_RS18280 3694096..3694338 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CRN23_RS18285 3694416..3696326 - 1911 WP_009486549.1 BglG family transcription antiterminator -
CRN23_RS18290 3696349..3697503 - 1155 WP_002886900.1 lactonase family protein -
CRN23_RS18295 3697570..3698310 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T86364 WP_009486548.1 NZ_CP023913:c3694106-3693822 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T86364 NZ_CP023913:c3694106-3693822 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT86364 WP_002886901.1 NZ_CP023913:c3694338-3694096 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT86364 NZ_CP023913:c3694338-3694096 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References