Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 2986..3508 Replicon plasmid unnamed5
Accession NZ_CP023905
Organism Escherichia coli strain FDAARGOS_433

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag CRN16_RS26825 Protein ID WP_000220561.1
Coordinates 2986..3267 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag CRN16_RS26830 Protein ID WP_000121743.1
Coordinates 3257..3508 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN16_RS26795 348..575 - 228 WP_000801440.1 hypothetical protein -
CRN16_RS26800 562..813 - 252 WP_001230707.1 hypothetical protein -
CRN16_RS26805 810..1352 - 543 WP_001083906.1 hypothetical protein -
CRN16_RS26810 1457..1972 - 516 WP_001025397.1 J domain-containing protein -
CRN16_RS26820 2612..2962 - 351 WP_000312755.1 hypothetical protein -
CRN16_RS26825 2986..3267 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CRN16_RS26830 3257..3508 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
CRN16_RS26840 4875..5882 + 1008 WP_000243325.1 replication initiation protein -
CRN16_RS26845 5948..6352 + 405 WP_000654312.1 hypothetical protein -
CRN16_RS26850 6488..7015 + 528 WP_000577047.1 DUF2726 domain-containing protein -
CRN16_RS26865 7587..7838 - 252 WP_000905714.1 hypothetical protein -
CRN16_RS26870 7875..8177 - 303 WP_001096506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35225 35225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T86350 WP_000220561.1 NZ_CP023905:c3267-2986 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T86350 NZ_CP023905:c3267-2986 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTTGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATATGCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT86350 WP_000121743.1 NZ_CP023905:c3508-3257 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT86350 NZ_CP023905:c3508-3257 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References