Detailed information of TA system TA086298

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 5070531..5071351
• Replicon: chromosome
• Accession: NZ_CP023853
• Organism: Escherichia coli strain 2/0

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: CRT29_RS25235
• Protein ID: WP_001054379.1
• Coordinates: 5071094..5071351 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: CRT29_RS25230
• Protein ID: WP_000123957.1
• Coordinates: 5070531..5071082 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRT29_RS25205	5066225..5067538	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
CRT29_RS25210	5067550..5067828	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
CRT29_RS25215	5067825..5068946	-	1122	WP_000010833.1	M42 family metallopeptidase	-
CRT29_RS26955	5069191..5069307	-	117	Protein_4814	VOC family protein	-
CRT29_RS25220	5069345..5069605	-	261	WP_000077645.1	hypothetical protein	-
CRT29_RS25225	5069733..5070479	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
CRT29_RS25230	5070531..5071082	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
CRT29_RS25235	5071094..5071351	-	258	WP_001054379.1	YjhX family toxin	Toxin
CRT29_RS25240	5071728..5071892	-	165	Protein_4819	GNAT family N-acetyltransferase	-
CRT29_RS25250	5073135..5074241	+	1107	Protein_4821	helicase YjhR	-
CRT29_RS25255	5074824..5075804	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T86298 WP_001054379.1 NZ_CP023853:c5071351-5071094 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T86298 NZ_CP023853:c5071351-5071094 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT86298 WP_000123957.1 NZ_CP023853:c5071082-5070531 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT86298 NZ_CP023853:c5071082-5070531 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030