Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 2295184..2296015 | Replicon | chromosome |
Accession | NZ_CP023853 | ||
Organism | Escherichia coli strain 2/0 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A066T988 |
Locus tag | CRT29_RS11810 | Protein ID | WP_000854815.1 |
Coordinates | 2295641..2296015 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A061Y7A8 |
Locus tag | CRT29_RS11805 | Protein ID | WP_001280918.1 |
Coordinates | 2295184..2295552 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CRT29_RS11750 | 2290273..2291019 | + | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
CRT29_RS11760 | 2291102..2291452 | + | 351 | Protein_2264 | hypothetical protein | - |
CRT29_RS11765 | 2291468..2291878 | + | 411 | WP_000846703.1 | hypothetical protein | - |
CRT29_RS11775 | 2292099..2292917 | + | 819 | WP_001542275.1 | DUF945 domain-containing protein | - |
CRT29_RS11780 | 2292917..2293162 | + | 246 | WP_001164966.1 | hypothetical protein | - |
CRT29_RS11785 | 2293256..2293729 | + | 474 | WP_001542276.1 | antirestriction protein | - |
CRT29_RS11790 | 2293745..2294221 | + | 477 | WP_001186200.1 | RadC family protein | - |
CRT29_RS11795 | 2294284..2294505 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
CRT29_RS11800 | 2294524..2295168 | + | 645 | WP_000086752.1 | hypothetical protein | - |
CRT29_RS11805 | 2295184..2295552 | + | 369 | WP_001280918.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
CRT29_RS11810 | 2295641..2296015 | + | 375 | WP_000854815.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
CRT29_RS11815 | 2296012..2296206 | + | 195 | WP_000988600.1 | hypothetical protein | - |
CRT29_RS11820 | 2296219..2296332 | + | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
CRT29_RS11825 | 2296621..2296767 | - | 147 | Protein_2276 | transposase domain-containing protein | - |
CRT29_RS11830 | 2296821..2297003 | + | 183 | WP_001296208.1 | hypothetical protein | - |
CRT29_RS11835 | 2297104..2297433 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
CRT29_RS11840 | 2297605..2298663 | - | 1059 | WP_001200889.1 | FUSC family protein | - |
CRT29_RS11845 | 2298861..2299334 | - | 474 | WP_001105368.1 | DNA gyrase inhibitor SbmC | - |
CRT29_RS11850 | 2299453..2300619 | - | 1167 | WP_001296209.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13829.83 Da Isoelectric Point: 7.1326
>T86286 WP_000854815.1 NZ_CP023853:2295641-2296015 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T86286 NZ_CP023853:2295641-2296015 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13811.70 Da Isoelectric Point: 6.4767
>AT86286 WP_001280918.1 NZ_CP023853:2295184-2295552 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT86286 NZ_CP023853:2295184-2295552 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A066T988 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061Y7A8 |