Detailed information of TA system TA086129

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 5025682..5026502
• Replicon: chromosome
• Accession: NZ_CP023826
• Organism: Escherichia coli strain 4/4

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: CRT43_RS25130
• Protein ID: WP_001054379.1
• Coordinates: 5026245..5026502 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: CRT43_RS25125
• Protein ID: WP_000123957.1
• Coordinates: 5025682..5026233 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRT43_RS25100	5021376..5022689	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
CRT43_RS25105	5022701..5022979	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
CRT43_RS25110	5022976..5024097	-	1122	WP_000010833.1	M42 family metallopeptidase	-
CRT43_RS27765	5024342..5024458	-	117	Protein_4805	VOC family protein	-
CRT43_RS25115	5024496..5024756	-	261	WP_000077645.1	hypothetical protein	-
CRT43_RS25120	5024884..5025630	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
CRT43_RS25125	5025682..5026233	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
CRT43_RS25130	5026245..5026502	-	258	WP_001054379.1	YjhX family toxin	Toxin
CRT43_RS25135	5026879..5027043	-	165	Protein_4810	GNAT family N-acetyltransferase	-
CRT43_RS25145	5028286..5029392	+	1107	Protein_4812	helicase YjhR	-
CRT43_RS25150	5029975..5030955	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T86129 WP_001054379.1 NZ_CP023826:c5026502-5026245 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T86129 NZ_CP023826:c5026502-5026245 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT86129 WP_000123957.1 NZ_CP023826:c5026233-5025682 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT86129 NZ_CP023826:c5026233-5025682 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030