Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4717290..4718125 Replicon chromosome
Accession NZ_CP023820
Organism Escherichia coli strain 7/2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag CRT46_RS23005 Protein ID WP_029701676.1
Coordinates 4717290..4717667 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag CRT46_RS23010 Protein ID WP_021553056.1
Coordinates 4717757..4718125 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRT46_RS22985 4713657..4715195 - 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -
CRT46_RS22990 4715944..4716786 - 843 WP_022645115.1 DUF4942 domain-containing protein -
CRT46_RS22995 4716871..4717065 - 195 WP_024181941.1 DUF957 domain-containing protein -
CRT46_RS23000 4717144..4717293 - 150 Protein_4398 hypothetical protein -
CRT46_RS23005 4717290..4717667 - 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
CRT46_RS23010 4717757..4718125 - 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CRT46_RS23015 4718288..4718509 - 222 WP_000692345.1 DUF987 domain-containing protein -
CRT46_RS23020 4718574..4719050 - 477 WP_021553055.1 RadC family protein -
CRT46_RS23025 4719066..4719545 - 480 WP_001564060.1 antirestriction protein -
CRT46_RS23030 4719811..4720629 - 819 WP_001175165.1 DUF945 domain-containing protein -
CRT46_RS23035 4720719..4720952 - 234 WP_001278293.1 DUF905 family protein -
CRT46_RS23040 4720958..4721635 - 678 WP_001097302.1 hypothetical protein -
CRT46_RS23045 4721783..4722463 - 681 WP_029702103.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T86092 WP_029701676.1 NZ_CP023820:c4717667-4717290 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T86092 NZ_CP023820:c4717667-4717290 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT86092 WP_021553056.1 NZ_CP023820:c4718125-4717757 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT86092 NZ_CP023820:c4718125-4717757 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References