Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 3388900..3389732 | Replicon | chromosome |
Accession | NZ_CP023820 | ||
Organism | Escherichia coli strain 7/2 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A3P5UBZ5 |
Locus tag | CRT46_RS16700 | Protein ID | WP_001094454.1 |
Coordinates | 3389358..3389732 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A3G8RJV8 |
Locus tag | CRT46_RS16695 | Protein ID | WP_001320394.1 |
Coordinates | 3388900..3389268 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CRT46_RS16655 | 3385187..3385642 | + | 456 | WP_000581493.1 | hypothetical protein | - |
CRT46_RS16660 | 3385721..3385954 | + | 234 | WP_001119719.1 | DUF905 family protein | - |
CRT46_RS16670 | 3386054..3386872 | + | 819 | WP_001234642.1 | DUF945 domain-containing protein | - |
CRT46_RS16675 | 3386927..3387412 | + | 486 | WP_029701480.1 | antirestriction protein | - |
CRT46_RS16680 | 3387428..3387904 | + | 477 | WP_001347688.1 | RadC family protein | - |
CRT46_RS16685 | 3387967..3388188 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
CRT46_RS16690 | 3388207..3388850 | + | 644 | Protein_3201 | antitoxin of toxin-antitoxin stability system | - |
CRT46_RS16695 | 3388900..3389268 | + | 369 | WP_001320394.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
CRT46_RS16700 | 3389358..3389732 | + | 375 | WP_001094454.1 | TA system toxin CbtA family protein | Toxin |
CRT46_RS16705 | 3389729..3390217 | + | 489 | WP_000777545.1 | hypothetical protein | - |
CRT46_RS16710 | 3390229..3390426 | + | 198 | WP_000839276.1 | DUF957 domain-containing protein | - |
CRT46_RS16715 | 3390523..3391092 | + | 570 | WP_001290250.1 | DUF4942 domain-containing protein | - |
CRT46_RS16720 | 3391435..3391605 | + | 171 | Protein_3207 | IS110 family transposase | - |
CRT46_RS16725 | 3392416..3393399 | + | 984 | WP_001298261.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
CRT46_RS16730 | 3393471..3394619 | + | 1149 | WP_000905922.1 | capsule polysaccharide export inner-membrane protein KpsE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14059.10 Da Isoelectric Point: 9.2447
>T86087 WP_001094454.1 NZ_CP023820:3389358-3389732 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T86087 NZ_CP023820:3389358-3389732 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13623.22 Da Isoelectric Point: 6.4783
>AT86087 WP_001320394.1 NZ_CP023820:3388900-3389268 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ
Download Length: 369 bp
>AT86087 NZ_CP023820:3388900-3389268 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3P5UBZ5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G8RJV8 |