Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3388900..3389732 Replicon chromosome
Accession NZ_CP023820
Organism Escherichia coli strain 7/2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag CRT46_RS16700 Protein ID WP_001094454.1
Coordinates 3389358..3389732 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag CRT46_RS16695 Protein ID WP_001320394.1
Coordinates 3388900..3389268 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRT46_RS16655 3385187..3385642 + 456 WP_000581493.1 hypothetical protein -
CRT46_RS16660 3385721..3385954 + 234 WP_001119719.1 DUF905 family protein -
CRT46_RS16670 3386054..3386872 + 819 WP_001234642.1 DUF945 domain-containing protein -
CRT46_RS16675 3386927..3387412 + 486 WP_029701480.1 antirestriction protein -
CRT46_RS16680 3387428..3387904 + 477 WP_001347688.1 RadC family protein -
CRT46_RS16685 3387967..3388188 + 222 WP_000692300.1 DUF987 domain-containing protein -
CRT46_RS16690 3388207..3388850 + 644 Protein_3201 antitoxin of toxin-antitoxin stability system -
CRT46_RS16695 3388900..3389268 + 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CRT46_RS16700 3389358..3389732 + 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
CRT46_RS16705 3389729..3390217 + 489 WP_000777545.1 hypothetical protein -
CRT46_RS16710 3390229..3390426 + 198 WP_000839276.1 DUF957 domain-containing protein -
CRT46_RS16715 3390523..3391092 + 570 WP_001290250.1 DUF4942 domain-containing protein -
CRT46_RS16720 3391435..3391605 + 171 Protein_3207 IS110 family transposase -
CRT46_RS16725 3392416..3393399 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
CRT46_RS16730 3393471..3394619 + 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T86087 WP_001094454.1 NZ_CP023820:3389358-3389732 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T86087 NZ_CP023820:3389358-3389732 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT86087 WP_001320394.1 NZ_CP023820:3388900-3389268 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT86087 NZ_CP023820:3388900-3389268 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References