Detailed information of TA system TA086000

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2146975..2147522
• Replicon: chromosome
• Accession: NZ_CP023778
• Organism: Nocardia terpenica strain NC_YFY_NT001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CRH09_RS09580
• Protein ID: WP_098698492.1
• Coordinates: 2147295..2147522 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CRH09_RS09575
• Protein ID: WP_098698491.1
• Coordinates: 2146975..2147256 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRH09_RS09545	2142204..2142425	+	222	WP_067583497.1	acyl carrier protein	-
CRH09_RS09550	2142422..2143828	+	1407	WP_098693613.1	FAD-dependent oxidoreductase	-
CRH09_RS09555	2143825..2145231	+	1407	WP_098693614.1	lysine 2,3-aminomutase	-
CRH09_RS09560	2145228..2145707	+	480	WP_098693615.1	MaoC family dehydratase N-terminal domain-containing protein	-
CRH09_RS09565	2145704..2146165	+	462	WP_098693616.1	MaoC family dehydratase N-terminal domain-containing protein	-
CRH09_RS09570	2146162..2146953	+	792	WP_098693617.1	AfsR/SARP family transcriptional regulator	-
CRH09_RS09575	2146975..2147256	+	282	WP_098698491.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CRH09_RS09580	2147295..2147522	+	228	WP_098698492.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CRH09_RS09585	2147658..2148659	-	1002	WP_198407197.1	DUF2156 domain-containing protein	-
CRH09_RS09590	2148804..2150411	+	1608	WP_098698494.1	aldehyde dehydrogenase	-
CRH09_RS09595	2150411..2151547	+	1137	WP_098693618.1	acyl-CoA/acyl-ACP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (23-73)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-76)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8712.12 Da
• Isoelectric Point: 10.1347

>T86000 WP_098698492.1 NZ_CP023778:2147295-2147522 [Nocardia terpenica]
MLTERLPESVAVAAYEFMTGPLLDNPYRVGKRLLPPLDDRFSARRGTYRIIYRIDDKRMVVTVVDVGHRSNIYRA

Nucleotide

• Length: 228 bp

>T86000 NZ_CP023778:2147295-2147522 [Nocardia terpenica]
ATGCTGACCGAGCGGCTACCCGAATCGGTTGCTGTCGCGGCCTACGAGTTCATGACCGGGCCGCTACTCGACAATCCCTA
CAGGGTCGGGAAGCGACTCCTGCCGCCCCTGGACGACAGATTCTCGGCTCGACGCGGCACCTACCGAATCATCTATCGCA
TCGACGACAAACGAATGGTTGTCACGGTGGTGGATGTCGGACATCGAAGCAATATCTACCGGGCATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10112.58 Da
• Isoelectric Point: 4.5546

>AT86000 WP_098698491.1 NZ_CP023778:2146975-2147256 [Nocardia terpenica]
MVILMTMKLAEVKATLSEVVHRVHTQHERVTITVHGEPAAILIAPDDLEALEETIAILADNETVARLASSDAELARGEVV
TGDELAKAMDNRR

Nucleotide

• Length: 282 bp

>AT86000 NZ_CP023778:2146975-2147256 [Nocardia terpenica]
CTGGTCATACTTATGACTATGAAGCTCGCCGAGGTGAAAGCGACCCTGTCCGAGGTTGTGCACCGTGTCCACACCCAACA
CGAGCGCGTCACCATCACCGTGCACGGAGAGCCCGCCGCGATCCTCATCGCACCCGATGATCTCGAAGCGCTCGAGGAAA
CAATCGCCATTCTCGCCGACAACGAAACGGTCGCCCGGCTTGCCTCATCCGACGCCGAACTGGCGCGTGGGGAGGTCGTC
ACCGGCGACGAACTGGCCAAGGCCATGGACAACCGGCGGTGA