85998

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2408076..2409823 Replicon chromosome
Accession NZ_CP023776
Organism Burkholderia pseudomallei strain BPHN1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CNX72_RS33505 Protein ID WP_120183936.1
Coordinates 2408477..2409823 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CNX72_RS33500 Protein ID WP_120183935.1
Coordinates 2408076..2408480 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNX72_RS33490 2404613..2407009 - 2397 WP_076887865.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
CNX72_RS38580 2407475..2407738 + 264 WP_004199789.1 hypothetical protein -
CNX72_RS33500 2408076..2408480 + 405 WP_120183935.1 helix-turn-helix domain-containing protein Antitoxin
CNX72_RS33505 2408477..2409823 + 1347 WP_120183936.1 type II toxin-antitoxin system HipA family toxin Toxin
CNX72_RS33510 2409980..2410432 - 453 WP_004198842.1 hypothetical protein -
CNX72_RS38585 2410533..2410679 - 147 WP_004199790.1 hypothetical protein -
CNX72_RS33520 2410849..2411763 - 915 WP_004198844.1 LysR family transcriptional regulator -
CNX72_RS33525 2411930..2412883 + 954 WP_004539421.1 agmatinase -
CNX72_RS33535 2413160..2413501 + 342 WP_004539420.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(156-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-71)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49648.60 Da        Isoelectric Point: 9.6807

>T85998 WP_120183936.1 NZ_CP023776:2408477-2409823 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIRRR
IAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSIAG
AQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVVER
FDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAKNF
SIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALIDT
LTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1347 bp

>T85998 NZ_CP023776:2408477-2409823 [Burkholderia pseudomallei]
GTGAGCGCCCGCCGCGCACGCGCGACGCGCCTGCACCTGTGGATGAACGGCCTGCCCGTCGGCTACTGGGAGCACGCGCG
CGACGGCGAGCGCCTTGTCTACTTCGACGAATGGATCGGCGATCCGCAAGGCCGGCCGCTGTCGCTGCCGTTCACGCCGG
GCAACCAGCCGTATCGCGGTCGGCTCGTCAGCGATTATTTCGACAACCTGCTGCCCGACAGCGAGCCGATCCGCCGGCGA
ATCGCGATGCGCTACCGCACGGGCGGCACGTCCGCGTTCGCGCTGCTCGCGACGCTCGGCCGCGATTGCGTCGGCGCGCT
GCAGATGCTGCCGCCCGACGAAGCGCCGGACGACATCGAACGCATCCGCGGCCACGCGCTCGCCGACGCGGACATCGCGC
GCCTGCTGCGCGAAGTCACGTCCGCGCCGCAGGCCGGCCGGCACGCGCCGCTCGACGATCTGCGCCTGTCGATCGCCGGC
GCGCAGGAGAAGACCGCGCTGCTGCGCCATCGCGGCCGCTGGCTGCTGCCCGAAGGGAGCACGCCGACCACGCACATCCT
GAAGCTGCCGCTCGGGCTCGTCGGCAACCGGCGCGCCGACATGCGCACGTCGGTCGAGAACGAATGGCTGTGCGCGCGGA
TCGTCGCCGCGTACGGGTTGCCCGTCGCGCGCTGCGACATCGCGCAGTTCGACGATCAGAAAGCGCTCGTCGTCGAGCGC
TTCGACCGCCGGCCGTCGCGCGACGCGCGCTGGCTCCTGCGGCTGCCGCAGGAAGACATGTGCCAGGCAACCGGCACGTC
CGCGCTCGACAAATATCAGGCCGACGGCGGCCCCGGCATCGAGACGATCATGGAAGTGCTCGCCGGCTCCGAACACGCGC
GGGACGACCGCCGCGCGTTCTTCGCGGCGCAGATCGTGTTCTGGCTGCTCGCCGCGACCGACGGCCACGCGAAGAACTTC
AGCATCGCGCACCTGCCCGGCAACCGCTACCGTTCGACGCCGCTTTACGACGTGCTGTCCGCGCATCCGGTCATCGGCCG
GGGCGCGAACCAGTTGCCCGCGCAGCGCGCGCGGCTCGCGATGGGCGTGCGCGGCAAGCACATCCACTATCCGCTGCACC
AGATCCGGCGGCGGCACTGGATCGCGCAGGGCCAGCGCGTCGGCTTCGCGCCCGCCGACGTCGACGCGCTGATCGACACG
CTGACCGCGCGCACCGCGGACGTCGTCGACGCGGTGTCGGCGCGGCTGCCGCGCGATTTTCCGCGCGACGTCGCCGATGC
GATCTTCAGCGGAATGCTCGGCCTGAGCGCAAGGCTCGCCGGCGACGCGGCCGCGCGCGCACCATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14191.48 Da        Isoelectric Point: 11.7233

>AT85998 WP_120183935.1 NZ_CP023776:2408076-2408480 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLLKVLRALDIELTLTLTQVYAA
PAGKDKGEAAKTAAGARAGARRAAPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 405 bp

>AT85998 NZ_CP023776:2408076-2408480 [Burkholderia pseudomallei]
ATGGCCATCCTCATCGAGCACGAGATCAAGACACTCGGCCAGCTGCGGCCGATTCTGCGCGGCTTCCGCAAATCGGCCGG
ATTGACGCAGGCGATGCTCGCGAGCCGCCTCGGCGTCACGCAGCAGACCTACGCGCAGTTCGAGGCGAACCCGGCGTCGG
CGAGCGTCGAGCGGCTGCTCAAGGTGCTGCGCGCGCTCGACATCGAACTCACGCTCACGCTCACGCAGGTCTACGCCGCG
CCCGCGGGCAAGGACAAGGGCGAGGCTGCGAAGACGGCCGCAGGCGCGCGCGCGGGCGCGCGACGTGCCGCGCCGCCCGC
GTCCGCGCCCGCTCCGAGCGCCGCCGGGCGCGCGCCCCGCCCCGCCCGCAAGCGCGCCGCCCCGAAAAAGCGGGAGGACT
GGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References