85997

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1470015..1471771 Replicon chromosome
Accession NZ_CP023776
Organism Burkholderia pseudomallei strain BPHN1

Toxin (Protein)


Gene name doc Uniprot ID A0A0E1U4R2
Locus tag CNX72_RS29035 Protein ID WP_004543311.1
Coordinates 1470015..1470920 (+) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag CNX72_RS29040 Protein ID WP_004195450.1
Coordinates 1470917..1471771 (+) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNX72_RS29000 1465412..1466500 - 1089 WP_004184835.1 porin -
CNX72_RS29010 1466933..1467250 + 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
CNX72_RS29015 1467252..1467563 + 312 WP_004184841.1 hypothetical protein -
CNX72_RS29020 1467598..1468665 + 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CNX72_RS29025 1468662..1469432 + 771 WP_004524000.1 SDR family oxidoreductase -
CNX72_RS29030 1469471..1469998 + 528 WP_004524001.1 cupin domain-containing protein -
CNX72_RS29035 1470015..1470920 + 906 WP_004543311.1 alpha/beta fold hydrolase Toxin
CNX72_RS29040 1470917..1471771 + 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
CNX72_RS29045 1471768..1472565 + 798 WP_004195447.1 SDR family oxidoreductase -
CNX72_RS29050 1472558..1474231 + 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
CNX72_RS29055 1474224..1475039 + 816 WP_004528162.1 aspartate dehydrogenase -
CNX72_RS29060 1475065..1476555 + 1491 WP_004524006.1 aldehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(54-284)

Antitoxin

(143-265)


Sequences


Toxin        


Download         Length: 302 a.a.        Molecular weight: 30604.78 Da        Isoelectric Point: 8.7258

>T85997 WP_004543311.1 NZ_CP023776:1470015-1470920 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASYLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

>T85997 NZ_CP023776:1470015-1470920 [Burkholderia pseudomallei]
ATGAGCACGATTTCCACGACGACAACCGAGGCGGGCGCGGCGCCGTTCGCCGCGCTGCTCGCACGCTTTCCCGAGCGGCG
CGCGGCGGTGGGCGGCGCCGGCGTGATCGGCTATCGCGAGGCGGGCGAAGCCCATGCGCGGCGCGCCGGATGCGAACCCG
TCGTGCTGCTGCACGGGATCGGCTCGGGGGCGGCGTCGTGGGTGCGCCAGCTCGATGCGCTCGGCGCGACGCGTCGCGCG
CTCGCGTGGGACGCACCCGGCTATGGCGCATCGTCGCGCGTCGCAGCCGATTCGCCCGTCGCGGCGGACTACGCGGCGTC
GCTCGCCGCGTGGCTCGACGCGCTGCGCATCGAGCGCTGCGTGCTCGTCGGCCATTCGCTCGGCGCGATCATGGCCGGCG
CGTTTGCACGGATCGCGGGCGAGCGGCTGGCGGGATTGCTGCTGATTTCCCCCGCGGGCGGCTACGGCAGCGCGCCCGCC
GACGTGCGGGCCGGGCGGCGCGACAGCCGCCTTGCGTTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGCCGAGCGCAG
CGCGAACATGCTGTCCGCGCAGGCGAGCGGCGCGGCGCGCGAGTGGGTGCGCTGGAACATGGCGCGCATCGCGCCCGCGG
GCTACGCGCAGGCGACGCATCTGCTCGCGAACGCGGATCTCGCCTCCTATCTTGCCCATTGCCGCGGCCGCATCGCGGTC
GCGGTCGGCGGCGACGATGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCGCGGGCGGCGGGCGTCGGGCTGCAGGT
GATCGCGCGCGCGGGGCACGCCGGCTACGTCGAAGCGCCCGATGCATACAGCGCGTTGATCGACGCCTTTTGCCGTCAAT
GCGACGGATCGCGAGGCACACCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT85997 WP_004195450.1 NZ_CP023776:1470917-1471771 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp

>AT85997 NZ_CP023776:1470917-1471771 [Burkholderia pseudomallei]
ATGAGCGAGCCGCTGCTGAAGGACGCCGACGACGCGAGGAATGATTCGAACTACGTCGTACCGGGGCTCGAGCGCGGGCT
GCGGATCCTGGCCGAGTTCTCGCCGCGAGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTATCGCCTG
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAAG
CCTGCGCGATGCGACGGGCTTCACCGCGCACATCGTGATTCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAAA
ACGCGGGGAACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCGCAGTTGCGCGCGCTGTATCCGGAGCGGGCGCTCGAACGCGTGACGAAGGCGACGCC
CGAGACCGTCGACGCGCTCTTCGACGTGATCCGCGACGATGCGCGGCGCGGCTACGGCATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCCGTGCGCAACGAAGCGAGCCGGATCGTCGCGGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGATGCGGCGCTCGTCGCCGAAGGGCTCGTCGAGAAGGTCGTGCGTGCGGCGGCCGAGCTGTCGCGGCGGTT
GAACTATCGGTCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E1U4R2


Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References