Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1801263..1801749 Replicon chromosome
Accession NZ_CP023769
Organism Streptococcus pyogenes strain HarveyGAS

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag CRD75_RS09090 Protein ID WP_014407961.1
Coordinates 1801263..1801532 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag CRD75_RS09095 Protein ID WP_014407962.1
Coordinates 1801522..1801749 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRD75_RS09075 1796754..1797831 + 1078 Protein_1676 DUF4097 family beta strand repeat protein -
CRD75_RS09080 1797948..1800221 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
CRD75_RS09085 1800356..1800889 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
CRD75_RS09090 1801263..1801532 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CRD75_RS09095 1801522..1801749 - 228 WP_014407962.1 hypothetical protein Antitoxin
CRD75_RS09100 1801902..1802273 - 372 WP_011285302.1 DUF1492 domain-containing protein -
CRD75_RS09105 1802263..1802610 - 348 WP_011285303.1 DUF1492 domain-containing protein -
CRD75_RS09110 1802891..1803136 - 246 WP_011285304.1 hypothetical protein -
CRD75_RS09115 1803111..1803386 - 276 WP_014407964.1 hypothetical protein -
CRD75_RS09120 1803376..1803714 - 339 WP_030126557.1 replication protein -
CRD75_RS09125 1803756..1804022 - 267 WP_011285307.1 hypothetical protein -
CRD75_RS09130 1804019..1804807 - 789 WP_011285308.1 hypothetical protein -
CRD75_RS09545 1804898..1805056 - 159 WP_011285309.1 hypothetical protein -
CRD75_RS09135 1805070..1805315 - 246 WP_011285310.1 hypothetical protein -
CRD75_RS09140 1805311..1805637 - 327 Protein_1690 hypothetical protein -
CRD75_RS09550 1805639..1805812 - 174 WP_011285312.1 hypothetical protein -
CRD75_RS09145 1805818..1805991 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T85994 WP_014407961.1 NZ_CP023769:c1801532-1801263 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T85994 NZ_CP023769:c1801532-1801263 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT85994 WP_014407962.1 NZ_CP023769:c1801749-1801522 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT85994 NZ_CP023769:c1801749-1801522 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References