Detailed information of TA system TA085990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 5325363..5325978
• Replicon: chromosome
• Accession: NZ_CP023741
• Organism: Sphingobium yanoikuyae strain S72

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A6768_RS24760
• Protein ID: WP_097385339.1
• Coordinates: 5325363..5325659 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A6768_RS24765
• Protein ID: WP_097385719.1
• Coordinates: 5325697..5325978 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6768_RS24725	5321308..5321544	-	237	WP_172438711.1	ogr/Delta-like zinc finger family protein	-
A6768_RS24730	5321605..5322093	-	489	WP_097384353.1	hypothetical protein	-
A6768_RS24735	5322090..5322308	-	219	WP_097385335.1	hypothetical protein	-
A6768_RS24740	5322305..5322568	-	264	WP_097385336.1	hypothetical protein	-
A6768_RS24745	5322568..5322897	-	330	WP_097385337.1	helix-turn-helix domain-containing protein	-
A6768_RS24750	5322963..5323643	+	681	WP_097385338.1	helix-turn-helix transcriptional regulator	-
A6768_RS24755	5323661..5324059	+	399	WP_097385811.1	hypothetical protein	-
A6768_RS26055	5324196..5324795	+	600	WP_150131283.1	hypothetical protein	-
A6768_RS26060	5325023..5325208	+	186	WP_150131284.1	hypothetical protein	-
A6768_RS24760	5325363..5325659	+	297	WP_097385339.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6768_RS24765	5325697..5325978	+	282	WP_097385719.1	putative addiction module antidote protein	Antitoxin
A6768_RS24770	5325979..5326989	-	1011	WP_097385340.1	late control protein	-
A6768_RS24775	5326986..5327399	-	414	WP_097385812.1	phage tail protein	-
A6768_RS24780	5327405..5329807	-	2403	WP_097385341.1	phage tail tape measure protein	-
A6768_RS24785	5329807..5329947	-	141	WP_097385342.1	GpE family phage tail protein	-
A6768_RS24790	5329956..5330267	-	312	WP_097385343.1	phage tail assembly protein	-
A6768_RS24795	5330328..5330840	-	513	WP_097385344.1	phage major tail tube protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	5315044..5374004	58960

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-82)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10970.73 Da
• Isoelectric Point: 10.3094

>T85990 WP_097385339.1 NZ_CP023741:5325363-5325659 [Sphingobium yanoikuyae]
MKTIRRTDIFADWLKNLRDRAGAARIVARINRLAMGNPGQMRNLKGGVSEMKIDFGPGYRVYFTERNGELIVLLCGGDKK
SQDKDIGRAVAMVGELEE

Nucleotide

• Length: 297 bp

>T85990 NZ_CP023741:5325363-5325659 [Sphingobium yanoikuyae]
ATGAAGACGATCCGCCGCACCGACATTTTCGCTGACTGGCTGAAAAACCTGCGCGACCGTGCCGGTGCTGCCCGCATCGT
AGCTCGCATCAATCGATTGGCGATGGGCAATCCCGGCCAGATGCGGAACCTGAAGGGCGGTGTGAGCGAAATGAAGATCG
ACTTCGGCCCCGGATATCGCGTCTATTTTACCGAGCGAAACGGGGAATTGATTGTGCTGTTGTGCGGCGGCGACAAGAAG
TCGCAGGACAAGGATATTGGGCGCGCTGTGGCGATGGTCGGCGAACTGGAGGAGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10044.41 Da
• Isoelectric Point: 4.6286

>AT85990 WP_097385719.1 NZ_CP023741:5325697-5325978 [Sphingobium yanoikuyae]
MAIKTEPWDAAEFLGSEEDIRHYLEAAFEDGDPVVIRSAFADVARARGMTALAKDAGVSRETLYKAFAENGNPTLDTLMK
VTKALGVRLSIAA

Nucleotide

• Length: 282 bp

>AT85990 NZ_CP023741:5325697-5325978 [Sphingobium yanoikuyae]
ATGGCTATCAAAACGGAGCCGTGGGACGCGGCCGAGTTCCTTGGGTCGGAAGAGGATATCCGGCATTATCTTGAAGCGGC
ATTCGAGGATGGCGATCCTGTCGTGATCCGTTCGGCCTTTGCCGATGTGGCGCGTGCGCGCGGTATGACGGCGCTTGCCA
AGGATGCCGGTGTCTCGCGGGAGACGCTGTACAAAGCCTTTGCCGAGAACGGCAACCCAACGCTCGACACGCTGATGAAG
GTGACGAAGGCGCTGGGCGTCAGGTTGTCGATCGCAGCCTGA