Detailed information of TA system TA085989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 3579408..3580023
• Replicon: chromosome
• Accession: NZ_CP023741
• Organism: Sphingobium yanoikuyae strain S72

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: A6768_RS16585
• Protein ID: WP_097384358.1
• Coordinates: 3579408..3579704 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A6768_RS16590
• Protein ID: WP_097385719.1
• Coordinates: 3579742..3580023 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6768_RS16555	3576067..3576303	-	237	WP_172438711.1	ogr/Delta-like zinc finger family protein	-
A6768_RS16560	3576364..3576852	-	489	WP_097384353.1	hypothetical protein	-
A6768_RS16565	3576849..3577067	-	219	WP_097384354.1	hypothetical protein	-
A6768_RS25980	3577064..3577327	-	264	WP_150131260.1	hypothetical protein	-
A6768_RS16570	3577327..3577656	-	330	WP_097384355.1	helix-turn-helix domain-containing protein	-
A6768_RS16575	3577742..3578416	+	675	WP_097384356.1	helix-turn-helix transcriptional regulator	-
A6768_RS16580	3578416..3578838	+	423	WP_097384357.1	HIRAN domain-containing protein	-
A6768_RS25985	3578816..3579223	+	408	WP_150131261.1	hypothetical protein	-
A6768_RS16585	3579408..3579704	+	297	WP_097384358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6768_RS16590	3579742..3580023	+	282	WP_097385719.1	putative addiction module antidote protein	Antitoxin
A6768_RS16595	3580024..3581034	-	1011	WP_097384359.1	late control protein	-
A6768_RS16600	3581031..3581444	-	414	WP_097385720.1	phage tail protein	-
A6768_RS16605	3581450..3583852	-	2403	WP_097384360.1	phage tail tape measure protein	-
A6768_RS16610	3583852..3583992	-	141	WP_097384361.1	GpE family phage tail protein	-
A6768_RS16615	3584001..3584312	-	312	WP_097384362.1	phage tail assembly protein	-
A6768_RS16620	3584373..3584885	-	513	WP_097384363.1	phage major tail tube protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3565009..3605835	40826

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11056.87 Da
• Isoelectric Point: 10.2562

>T85989 WP_097384358.1 NZ_CP023741:3579408-3579704 [Sphingobium yanoikuyae]
MKTIRRTDIFADWLKNLRDRAGAARIEIRIKRLAMGNPGQMRNLKGGVSEMKIDFGPGYRVYFTERNGELIVLLCGGDKK
SQDKDIGRAVAMVGELEE

Nucleotide

• Length: 297 bp

>T85989 NZ_CP023741:3579408-3579704 [Sphingobium yanoikuyae]
ATGAAGACGATCCGCCGTACCGACATTTTCGCTGACTGGCTGAAAAACCTGCGCGACCGTGCCGGTGCTGCCCGCATCGA
AATCCGTATCAAGCGATTGGCGATGGGCAATCCCGGCCAGATGCGGAACCTGAAGGGCGGTGTGAGCGAAATGAAGATCG
ACTTCGGCCCCGGATATCGCGTCTATTTTACCGAGCGAAACGGGGAATTGATCGTGCTGTTGTGCGGCGGCGACAAGAAG
TCGCAGGACAAGGATATTGGGCGCGCTGTGGCGATGGTCGGCGAACTGGAGGAGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10044.41 Da
• Isoelectric Point: 4.6286

>AT85989 WP_097385719.1 NZ_CP023741:3579742-3580023 [Sphingobium yanoikuyae]
MAIKTEPWDAAEFLGSEEDIRHYLEAAFEDGDPVVIRSAFADVARARGMTALAKDAGVSRETLYKAFAENGNPTLDTLMK
VTKALGVRLSIAA

Nucleotide

• Length: 282 bp

>AT85989 NZ_CP023741:3579742-3580023 [Sphingobium yanoikuyae]
ATGGCTATTAAAACGGAGCCGTGGGACGCGGCCGAGTTCCTTGGGTCGGAAGAGGATATCCGGCATTATCTTGAAGCGGC
ATTCGAGGATGGCGATCCTGTCGTGATCCGTTCGGCCTTTGCCGATGTGGCGCGTGCGCGCGGTATGACGGCGCTTGCCA
AGGATGCCGGTGTCTCGCGGGAGACGCTGTACAAAGCCTTTGCCGAGAACGGCAACCCAACGCTCGACACGCTGATGAAG
GTGACGAAGGCCCTGGGCGTCAGGTTGTCGATCGCAGCCTGA