Detailed information of TA system TA085987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 312743..313298
• Replicon: chromosome
• Accession: NZ_CP023741
• Organism: Sphingobium yanoikuyae strain S72

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: A6768_RS01500
• Protein ID: WP_097382351.1
• Coordinates: 312990..313298 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A291MUN4
• Locus tag: A6768_RS01495
• Protein ID: WP_010337577.1
• Coordinates: 312743..312988 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A6768_RS01475	308072..308785	+	714	WP_037510644.1	SDR family oxidoreductase	-
A6768_RS01480	308958..310148	+	1191	WP_097385496.1	chromate efflux transporter	-
A6768_RS01485	310236..311216	+	981	WP_097382350.1	phosphatase PAP2 family protein	-
A6768_RS01490	311219..312595	-	1377	WP_069336151.1	amidohydrolase	-
A6768_RS01495	312743..312988	+	246	WP_010337577.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
A6768_RS01500	312990..313298	+	309	WP_097382351.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A6768_RS01505	313305..314819	-	1515	WP_097382352.1	peptidase S10	-
A6768_RS01510	314886..316163	-	1278	WP_097385497.1	MFS transporter	-
A6768_RS01515	316210..317607	-	1398	WP_097382353.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11873.59 Da
• Isoelectric Point: 6.4860

>T85987 WP_097382351.1 NZ_CP023741:312990-313298 [Sphingobium yanoikuyae]
MARYRLTRAASDDIAAIFIDGIERFGLVQADLYHAGLAAAFDLIAEYPFAVRLREEIMPPVRVRHYRAHLILYDLVEDSR
PLILRVRHGREDWQAREEGPDR

Nucleotide

• Length: 309 bp

>T85987 NZ_CP023741:312990-313298 [Sphingobium yanoikuyae]
ATGGCGCGCTATCGTCTGACCCGCGCGGCGTCGGACGATATCGCAGCGATCTTCATCGACGGGATCGAACGGTTTGGGCT
GGTGCAGGCCGATCTCTATCATGCCGGGTTGGCGGCGGCTTTCGACCTGATTGCCGAATATCCTTTTGCAGTGCGACTGC
GGGAGGAGATCATGCCGCCGGTACGGGTGCGCCACTATCGGGCGCATCTGATTCTCTATGACCTTGTCGAGGATAGCCGG
CCCCTCATCCTGCGGGTCCGCCATGGTCGGGAAGACTGGCAGGCGCGGGAGGAAGGGCCGGATCGTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9258.53 Da
• Isoelectric Point: 7.2027

>AT85987 WP_010337577.1 NZ_CP023741:312743-312988 [Sphingobium yanoikuyae]
MATMNISLPDPMKNWVEAQTATGRYSNASDYVRDLIRRDQERLAKVAHMQMLVDEARQGGISDETMEDIRVRALHQAGLK
R

Nucleotide

• Length: 246 bp

>AT85987 NZ_CP023741:312743-312988 [Sphingobium yanoikuyae]
ATGGCGACAATGAATATTTCTCTGCCCGATCCGATGAAGAACTGGGTCGAGGCACAGACGGCAACCGGCCGTTACAGCAA
TGCGAGCGATTATGTGCGTGACCTGATCCGGCGCGATCAGGAGCGGCTGGCGAAGGTCGCCCATATGCAGATGCTGGTCG
ATGAAGCGCGGCAGGGCGGGATCAGCGACGAGACGATGGAGGATATCCGCGTGCGGGCGCTGCATCAGGCCGGGTTGAAG
CGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A291MUN4