Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 110975..111587 Replicon chromosome
Accession NZ_CP023741
Organism Sphingobium yanoikuyae strain S72

Toxin (Protein)


Gene name PumA Uniprot ID A0A291MU76
Locus tag A6768_RS00550 Protein ID WP_010336738.1
Coordinates 110975..111265 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A291MU34
Locus tag A6768_RS00555 Protein ID WP_010336739.1
Coordinates 111300..111587 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6768_RS00530 106594..108033 + 1440 WP_097382239.1 porin -
A6768_RS00535 108049..109470 - 1422 WP_097385480.1 carboxylesterase family protein -
A6768_RS00540 109640..110014 - 375 WP_004210471.1 50S ribosomal protein L7/L12 -
A6768_RS00545 110087..110602 - 516 WP_004210472.1 50S ribosomal protein L10 -
A6768_RS00550 110975..111265 + 291 WP_010336738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A6768_RS00555 111300..111587 + 288 WP_010336739.1 putative addiction module antidote protein Antitoxin
A6768_RS00560 111643..113748 - 2106 WP_004210474.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
A6768_RS00565 113870..114352 + 483 WP_010336740.1 helix-turn-helix transcriptional regulator -
A6768_RS00570 114408..115514 + 1107 WP_004210476.1 histidine kinase -
A6768_RS00575 115511..116314 + 804 WP_004210477.1 LytTR family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-93)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10719.43 Da        Isoelectric Point: 10.8166

>T85986 WP_010336738.1 NZ_CP023741:110975-111265 [Sphingobium yanoikuyae]
MEVLQTPVFAEWFAALRDRRARSKIAGRIARFELGLLGDVKSVGDGVLEARVDFGPGYRLYFVRRGDRLIVLLVGGDKSS
QPRDIARAKDMAARID

Download         Length: 291 bp

>T85986 NZ_CP023741:110975-111265 [Sphingobium yanoikuyae]
ATGGAAGTGTTGCAAACCCCGGTCTTTGCAGAATGGTTTGCCGCGCTTCGCGATCGCCGGGCGCGGTCGAAGATTGCCGG
GCGGATTGCCCGCTTCGAACTGGGACTGCTGGGCGATGTGAAGTCGGTGGGCGATGGCGTGCTGGAGGCGCGTGTCGATT
TCGGTCCGGGCTATCGCCTTTATTTCGTGCGGCGCGGGGATCGGCTTATCGTCCTGCTGGTTGGTGGCGACAAGTCGAGC
CAGCCGCGGGACATTGCCAGGGCAAAGGATATGGCGGCCCGGATCGATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10221.88 Da        Isoelectric Point: 5.0637

>AT85986 WP_010336739.1 NZ_CP023741:111300-111587 [Sphingobium yanoikuyae]
MTIELTRFDAAEALTQAEDQAELLADAFATGDVHVITQAIGIVARAHGMTELAKETGMKRQQLYRMLGPEGNPTLGSMLK
LLPALGLRMRIEAAA

Download         Length: 288 bp

>AT85986 NZ_CP023741:111300-111587 [Sphingobium yanoikuyae]
ATGACGATCGAATTGACCCGCTTTGATGCGGCTGAGGCGCTGACGCAAGCGGAGGATCAGGCGGAACTGCTCGCCGATGC
GTTCGCCACCGGTGACGTGCATGTCATCACCCAGGCCATCGGGATCGTGGCACGGGCGCATGGCATGACCGAGCTGGCGA
AGGAGACCGGCATGAAGCGGCAGCAACTTTATCGGATGCTCGGCCCCGAAGGGAATCCGACGCTGGGCAGCATGTTGAAG
CTGCTGCCGGCGCTGGGCCTGCGGATGCGGATCGAGGCGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291MU76

Antitoxin

Source ID Structure
AlphaFold DB A0A291MU34

References