Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 26628..27262 Replicon plasmid pOB3b1
Accession NZ_CP023738
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name vapC Uniprot ID A0A1A6FHD3
Locus tag CQW49_RS21470 Protein ID WP_003612723.1
Coordinates 26628..27029 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1A6FGH4
Locus tag CQW49_RS21475 Protein ID WP_003612725.1
Coordinates 27026..27262 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CQW49_RS21460 24485..25405 + 921 WP_003612721.1 DNA-binding response regulator -
CQW49_RS21465 25512..26570 + 1059 WP_003612722.1 DUF2252 family protein -
CQW49_RS21470 26628..27029 - 402 WP_003612723.1 type II toxin-antitoxin system VapC family toxin Toxin
CQW49_RS21475 27026..27262 - 237 WP_003612725.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..285280 285280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(10-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13934.03 Da        Isoelectric Point: 6.7108

>T85984 WP_003612723.1 NZ_CP023738:c27029-26628 [Methylosinus trichosporium OB3b]
MTRYLLDTNIVSDLIRNPRGRVAAHIAHVGEANVCTSVIVAAELRYGCAKSGSKRLSAAVESLLGELAVLALEGPAAAEY
GAIRAGLERRGTPIGGNDLLIAAHALAIDATVVTANMDEFARVEGLKVQNWLA

Download         Length: 402 bp

>T85984 NZ_CP023738:c27029-26628 [Methylosinus trichosporium OB3b]
TTGACCCGCTATCTGCTGGATACGAACATCGTCTCCGATTTGATCAGGAATCCGCGAGGCCGGGTCGCCGCACATATCGC
TCATGTGGGCGAGGCCAATGTCTGCACCAGCGTCATCGTGGCCGCCGAGCTGCGCTACGGCTGCGCCAAGAGCGGCTCGA
AGCGGCTCTCCGCGGCGGTCGAGAGCCTGCTGGGAGAGCTGGCCGTGCTTGCTCTGGAAGGCCCCGCCGCCGCCGAATAT
GGGGCGATCCGGGCCGGGCTGGAACGACGGGGAACCCCGATCGGCGGCAATGACCTATTGATCGCCGCTCATGCTCTGGC
GATCGATGCGACGGTCGTGACCGCCAATATGGACGAATTCGCCCGAGTCGAGGGGCTGAAGGTGCAGAACTGGCTCGCAT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8935.25 Da        Isoelectric Point: 4.5447

>AT85984 WP_003612725.1 NZ_CP023738:c27262-27026 [Methylosinus trichosporium OB3b]
MGEARHVKLFRNGRNQAVRIPVEFELPGDEAIMRREGDRLVLEPTRKRGLLGLLETMEPIDEAFPEIEDQPPAPEPIF

Download         Length: 237 bp

>AT85984 NZ_CP023738:c27262-27026 [Methylosinus trichosporium OB3b]
ATGGGCGAGGCGCGGCATGTGAAGCTGTTTCGGAACGGGCGCAACCAGGCGGTGCGCATTCCCGTCGAGTTCGAGCTGCC
CGGCGACGAGGCGATCATGCGCCGCGAGGGCGATCGTCTCGTGCTGGAGCCGACGCGCAAGCGCGGTCTCCTGGGCCTGC
TCGAGACGATGGAGCCCATCGACGAGGCCTTCCCCGAGATCGAAGATCAGCCGCCCGCGCCGGAGCCGATCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FHD3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FGH4

References