Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2822952..2823748 Replicon chromosome
Accession NZ_CP023737
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A1A6FN69
Locus tag CQW49_RS13540 Protein ID WP_003608950.1
Coordinates 2822952..2823476 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A1A6FQL2
Locus tag CQW49_RS13545 Protein ID WP_003608948.1
Coordinates 2823473..2823748 (-) Length 92 a.a.

Genomic Context

CQW49_RS13535CQW49_RS13555CQW49_RS13560CQW49_RS13565CQW49_RS13520CQW49_RS13525CQW49_RS13530CQW49_RS13540CQW49_RS13545CQW49_RS13550
Location: 2821764..2822249 (486 bp)
Type: Others
Protein ID: WP_155931266.1
Location: 2825282..2825854 (573 bp)
Type: Others
Protein ID: WP_003608944.1
Location: 2826239..2827024 (786 bp)
Type: Others
Protein ID: WP_099831891.1
Location: 2827021..2828007 (987 bp)
Type: Others
Protein ID: WP_003608940.1
Location: 2818495..2819358 (864 bp)
Type: Others
Protein ID: WP_003608957.1
Location: 2819351..2820316 (966 bp)
Type: Others
Protein ID: WP_003608955.1
Location: 2820270..2821247 (978 bp)
Type: Others
Protein ID: WP_003608953.1
Location: 2822952..2823476 (525 bp)
Type: Toxin
Protein ID: WP_003608950.1
Location: 2823473..2823748 (276 bp)
Type: Antitoxin
Protein ID: WP_003608948.1
Location: 2823901..2825124 (1224 bp)
Type: Others
Protein ID: WP_003608946.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CQW49_RS135202818495..2819358-864WP_003608957.1triphosphoribosyl-dephospho-CoA synthase-
CQW49_RS135252819351..2820316-966WP_003608955.1RimK family alpha-L-glutamate ligase-
CQW49_RS135302820270..2821247-978WP_003608953.1methenyltetrahydromethanopterin cyclohydrolase-
CQW49_RS135352821764..2822249+486WP_155931266.1hypothetical protein-
CQW49_RS135402822952..2823476-525WP_003608950.1GNAT family N-acetyltransferaseToxin
CQW49_RS135452823473..2823748-276WP_003608948.1DUF1778 domain-containing proteinAntitoxin
CQW49_RS135502823901..2825124-1224WP_003608946.1alpha/beta hydrolase-
CQW49_RS135552825282..2825854+573WP_003608944.1L,D-transpeptidase-
CQW49_RS135602826239..2827024+786WP_099831891.13-methyl-2-oxobutanoate hydroxymethyltransferase-
CQW49_RS135652827021..2828007+987WP_003608940.1ferrochelatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--2816443..2972913156470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-119)

Antitoxin

Vibrio phage ICP1, Orf50

(10-85)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19142.95 Da        Isoelectric Point: 8.6771

>T85981 WP_003608950.1 NZ_CP023737:c2823476-2822952 [Methylosinus trichosporium OB3b]
MTALEWEEVSLGKIHDRNAFHCGEDHLDTYLKRYARQNHESGGAKCFVAAARDAPTRVLGFYTLSPASIEFARAPAVATR
GLGRYEVPVYRLGRLAVDRSVQGRGLGGRLLLRAAERCMAVAQQVGGVALLIDAKTEMVAEWYENYGALRLLDAPRSLIL
PFAVVAEAVRQGER

Download         Length: 525 bp

>T85981 NZ_CP023737:c2823476-2822952 [Methylosinus trichosporium OB3b]
ATGACGGCGCTGGAGTGGGAAGAAGTTTCGCTCGGCAAGATCCACGACCGCAACGCATTCCACTGCGGCGAGGATCATCT
CGATACCTATTTGAAACGCTACGCGCGCCAAAACCATGAAAGCGGCGGCGCGAAATGCTTCGTTGCGGCGGCGCGCGACG
CCCCCACGCGCGTTCTCGGCTTCTATACACTGAGCCCCGCGTCGATCGAATTTGCGCGCGCCCCTGCCGTTGCGACGCGC
GGCCTCGGTCGCTACGAGGTCCCGGTGTATCGGCTCGGCCGCTTGGCCGTCGATCGCAGCGTGCAAGGCCGGGGGCTCGG
CGGCCGCCTGCTGCTGCGCGCCGCGGAACGCTGCATGGCCGTCGCGCAGCAAGTCGGCGGCGTGGCTCTGCTGATCGACG
CCAAGACCGAAATGGTCGCGGAATGGTACGAAAACTACGGGGCACTACGTCTCCTCGATGCGCCGCGCTCGCTCATCCTG
CCCTTCGCCGTGGTGGCCGAAGCGGTGAGGCAAGGGGAGCGATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10167.76 Da        Isoelectric Point: 8.8518

>AT85981 WP_003608948.1 NZ_CP023737:c2823748-2823473 [Methylosinus trichosporium OB3b]
MPREHAETGRVELRLKPEDKAVLARAAALERLDLTSFILRAALPRAQDVIAQSERLKLSERDSLRVLDLLENPPAPTERL
TRAAKGGFVLE

Download         Length: 276 bp

>AT85981 NZ_CP023737:c2823748-2823473 [Methylosinus trichosporium OB3b]
ATGCCCCGCGAACATGCCGAAACTGGCCGGGTCGAGCTGCGGCTGAAGCCGGAGGACAAGGCTGTGCTGGCGCGCGCGGC
CGCGCTCGAGCGGCTCGATCTGACCAGCTTCATCCTGCGCGCCGCGCTGCCGCGCGCGCAGGATGTCATCGCGCAGTCCG
AGAGGCTGAAGCTGTCCGAGCGCGATTCCCTGCGCGTGCTCGACCTCTTGGAAAACCCCCCGGCCCCCACGGAGCGACTG
ACGCGCGCGGCGAAGGGCGGCTTCGTGCTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1A6FN69

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1A6FQL2

References