Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-YefM
Location 866481..866986 Replicon chromosome
Accession NZ_CP023737
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1A6FN25
Locus tag CQW49_RS04150 Protein ID WP_003613166.1
Coordinates 866732..866986 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A1A6FKR2
Locus tag CQW49_RS04145 Protein ID WP_003613168.1
Coordinates 866481..866735 (+) Length 85 a.a.

Genomic Context

CQW49_RS04130CQW49_RS04135CQW49_RS04140CQW49_RS04145CQW49_RS04150CQW49_RS04165CQW49_RS04170CQW49_RS04155CQW49_RS04160
Location: 863159..864058 (900 bp)
Type: Others
Protein ID: WP_003610339.1
Location: 864055..864975 (921 bp)
Type: Others
Protein ID: WP_003610338.1
Location: 865114..866289 (1176 bp)
Type: Others
Protein ID: WP_024749735.1
Location: 866481..866735 (255 bp)
Type: Antitoxin
Protein ID: WP_003613168.1
Location: 866732..866986 (255 bp)
Type: Toxin
Protein ID: WP_003613166.1
Location: 868471..870021 (1551 bp)
Type: Others
Protein ID: WP_003613162.1
Location: 870157..870675 (519 bp)
Type: Others
Protein ID: WP_003613161.1
Location: 867058..867792 (735 bp)
Type: Others
Protein ID: WP_003613165.1
Location: 867821..868342 (522 bp)
Type: Others
Protein ID: WP_003613164.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CQW49_RS04130863159..864058+900WP_003610339.1TIGR00282 family metallophosphoesterase-
CQW49_RS04135864055..864975+921WP_003610338.1neutral zinc metallopeptidase-
CQW49_RS04140865114..866289+1176WP_024749735.1IS4 family transposase-
CQW49_RS04145866481..866735+255WP_003613168.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
CQW49_RS04150866732..866986+255WP_003613166.1Txe/YoeB family addiction module toxinToxin
CQW49_RS04155867058..867792-735WP_003613165.1SDR family oxidoreductase-
CQW49_RS04160867821..868342-522WP_003613164.1hypothetical protein-
CQW49_RS04165868471..870021+1551WP_003613162.1bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase-
CQW49_RS04170870157..870675+519WP_003613161.1DUF1269 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10070.61 Da        Isoelectric Point: 8.4811

>T85978 WP_003613166.1 NZ_CP023737:866732-866986 [Methylosinus trichosporium OB3b]
MKLVFAEQAWEDYLYWQAQDPKIVERINQLVKECLQTPFSGTGKPEPLRGGLRGWWSRRITLEHRLVYRVEGESLMIAQC
RYHY

Download         Length: 255 bp

>T85978 NZ_CP023737:866732-866986 [Methylosinus trichosporium OB3b]
ATGAAGCTCGTCTTCGCCGAGCAGGCCTGGGAGGATTACCTGTATTGGCAGGCGCAGGACCCCAAGATTGTCGAGCGCAT
CAATCAACTCGTGAAGGAATGTCTGCAGACGCCCTTTTCCGGGACGGGAAAGCCCGAGCCGCTGCGCGGCGGCCTGCGCG
GCTGGTGGTCGCGGCGCATCACGCTCGAGCACAGGCTCGTCTATCGCGTGGAAGGCGAAAGCCTGATGATCGCGCAATGC
CGTTATCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9278.43 Da        Isoelectric Point: 5.7251

>AT85978 WP_003613168.1 NZ_CP023737:866481-866735 [Methylosinus trichosporium OB3b]
MRSTSYSDLRKNLAATLDRVTADHEPVVITRDRGKPAAVLISLEDFASYEETAHLLKSPRNAERLQAAIEALDAGEGKER
KLAE

Download         Length: 255 bp

>AT85978 NZ_CP023737:866481-866735 [Methylosinus trichosporium OB3b]
ATGCGCAGCACCTCCTACAGCGACCTCCGTAAAAATCTCGCCGCGACGCTCGACCGCGTGACCGCGGATCACGAGCCCGT
GGTGATCACGCGCGACCGCGGAAAGCCGGCCGCCGTGCTCATATCGCTCGAGGACTTCGCTTCCTATGAGGAGACCGCCC
ACCTCCTGAAGAGCCCCCGCAACGCCGAGCGGCTGCAGGCGGCGATCGAGGCGCTCGACGCGGGCGAGGGAAAAGAGCGC
AAGCTCGCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1A6FN25

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1A6FKR2

References