Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relE/YoeB-YefM
Location 866481..866986 Replicon chromosome
Accession NZ_CP023737
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1A6FN25
Locus tag CQW49_RS04150 Protein ID WP_003613166.1
Coordinates 866732..866986 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A1A6FKR2
Locus tag CQW49_RS04145 Protein ID WP_003613168.1
Coordinates 866481..866735 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CQW49_RS04130 863159..864058 + 900 WP_003610339.1 TIGR00282 family metallophosphoesterase -
CQW49_RS04135 864055..864975 + 921 WP_003610338.1 neutral zinc metallopeptidase -
CQW49_RS04140 865114..866289 + 1176 WP_024749735.1 IS4 family transposase -
CQW49_RS04145 866481..866735 + 255 WP_003613168.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CQW49_RS04150 866732..866986 + 255 WP_003613166.1 Txe/YoeB family addiction module toxin Toxin
CQW49_RS04155 867058..867792 - 735 WP_003613165.1 SDR family oxidoreductase -
CQW49_RS04160 867821..868342 - 522 WP_003613164.1 hypothetical protein -
CQW49_RS04165 868471..870021 + 1551 WP_003613162.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
CQW49_RS04170 870157..870675 + 519 WP_003613161.1 DUF1269 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10070.61 Da        Isoelectric Point: 8.4811

>T85978 WP_003613166.1 NZ_CP023737:866732-866986 [Methylosinus trichosporium OB3b]
MKLVFAEQAWEDYLYWQAQDPKIVERINQLVKECLQTPFSGTGKPEPLRGGLRGWWSRRITLEHRLVYRVEGESLMIAQC
RYHY

Download         Length: 255 bp

>T85978 NZ_CP023737:866732-866986 [Methylosinus trichosporium OB3b]
ATGAAGCTCGTCTTCGCCGAGCAGGCCTGGGAGGATTACCTGTATTGGCAGGCGCAGGACCCCAAGATTGTCGAGCGCAT
CAATCAACTCGTGAAGGAATGTCTGCAGACGCCCTTTTCCGGGACGGGAAAGCCCGAGCCGCTGCGCGGCGGCCTGCGCG
GCTGGTGGTCGCGGCGCATCACGCTCGAGCACAGGCTCGTCTATCGCGTGGAAGGCGAAAGCCTGATGATCGCGCAATGC
CGTTATCATTATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9278.43 Da        Isoelectric Point: 5.7251

>AT85978 WP_003613168.1 NZ_CP023737:866481-866735 [Methylosinus trichosporium OB3b]
MRSTSYSDLRKNLAATLDRVTADHEPVVITRDRGKPAAVLISLEDFASYEETAHLLKSPRNAERLQAAIEALDAGEGKER
KLAE

Download         Length: 255 bp

>AT85978 NZ_CP023737:866481-866735 [Methylosinus trichosporium OB3b]
ATGCGCAGCACCTCCTACAGCGACCTCCGTAAAAATCTCGCCGCGACGCTCGACCGCGTGACCGCGGATCACGAGCCCGT
GGTGATCACGCGCGACCGCGGAAAGCCGGCCGCCGTGCTCATATCGCTCGAGGACTTCGCTTCCTATGAGGAGACCGCCC
ACCTCCTGAAGAGCCCCCGCAACGCCGAGCGGCTGCAGGCGGCGATCGAGGCGCTCGACGCGGGCGAGGGAAAAGAGCGC
AAGCTCGCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FN25

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FKR2

References