Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 452962..453734 Replicon chromosome
Accession NZ_CP023737
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1A6FSR2
Locus tag CQW49_RS02160 Protein ID WP_065083547.1
Coordinates 453240..453734 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1A6FRN5
Locus tag CQW49_RS02155 Protein ID WP_003609827.1
Coordinates 452962..453243 (+) Length 94 a.a.

Genomic Context

CQW49_RS24270CQW49_RS02155CQW49_RS02160CQW49_RS02175CQW49_RS02145CQW49_RS02150CQW49_RS02165CQW49_RS02170
Location: 448798..448977 (180 bp)
Type: Others
Protein ID: WP_155931222.1
Location: 452962..453243 (282 bp)
Type: Antitoxin
Protein ID: WP_003609827.1
Location: 453240..453734 (495 bp)
Type: Toxin
Protein ID: WP_065083547.1
Location: 457971..458429 (459 bp)
Type: Others
Protein ID: WP_024749349.1
Location: 449008..451353 (2346 bp)
Type: Others
Protein ID: WP_003609830.1
Location: 451549..452844 (1296 bp)
Type: Others
Protein ID: WP_003609828.1
Location: 453781..454119 (339 bp)
Type: Others
Protein ID: WP_024749350.1
Location: 454227..457817 (3591 bp)
Type: Others
Protein ID: WP_099831727.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CQW49_RS24270448798..448977+180WP_155931222.1hypothetical protein-
CQW49_RS02145449008..451353-2346WP_003609830.1TonB-dependent receptor-
CQW49_RS02150451549..452844-1296WP_003609828.1dihydroorotase-
CQW49_RS02155452962..453243+282WP_003609827.1DUF1778 domain-containing proteinAntitoxin
CQW49_RS02160453240..453734+495WP_065083547.1GNAT family N-acetyltransferaseToxin
CQW49_RS02165453781..454119-339WP_024749350.1septum formation initiator family protein-
CQW49_RS02170454227..457817-3591WP_099831727.1hypothetical protein-
CQW49_RS02175457971..458429+459WP_024749349.1peroxiredoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(37-141)

Antitoxin

Vibrio phage ICP1, Orf50

(3-93)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17593.28 Da        Isoelectric Point: 6.8716

>T85977 WP_065083547.1 NZ_CP023737:453240-453734 [Methylosinus trichosporium OB3b]
MTLTAPEPIDESHIVNDFDSGVPVLDDWLMRRARANQASGASRAYVICEDRRVVGYYALAAGAVEISNATGRLRRNMPDP
VPIAVLGRLAIHRGFQGNGLGRALVRDAGQRVLQAADIIGIRGILVHVLSPEAEAFYHALGLEASALQPMTLMATLADLR
AALI

Download         Length: 495 bp

>T85977 NZ_CP023737:453240-453734 [Methylosinus trichosporium OB3b]
ATGACGCTCACTGCTCCCGAGCCGATCGATGAATCGCACATCGTCAATGACTTCGACTCTGGCGTTCCGGTCCTCGACGA
TTGGCTGATGCGCCGCGCCCGGGCGAACCAGGCGAGCGGCGCATCGCGCGCATATGTGATTTGCGAGGACCGGCGTGTCG
TCGGCTATTATGCGCTCGCCGCCGGCGCCGTCGAAATCTCGAATGCGACAGGACGCCTTCGCCGCAACATGCCCGATCCT
GTCCCGATCGCCGTGCTGGGACGATTGGCGATCCACCGCGGCTTCCAGGGAAACGGCCTCGGTCGCGCTCTCGTGCGGGA
CGCGGGGCAGCGTGTGCTGCAAGCCGCCGATATTATAGGGATTCGTGGAATTCTCGTTCACGTGCTCTCACCGGAAGCAG
AGGCTTTTTATCACGCCCTCGGCCTAGAGGCGTCGGCCTTGCAGCCCATGACGCTGATGGCGACGTTGGCCGATCTGCGC
GCAGCGTTGATTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10553.20 Da        Isoelectric Point: 11.0151

>AT85977 WP_003609827.1 NZ_CP023737:452962-453243 [Methylosinus trichosporium OB3b]
MTVKPQAKRDTLNVRVKPEDRSLIDRAARLLGKSRADFLLESARRAAHDVLLDQTLFKVSPQVYGEFIARLDAPPAPNER
LRRTMATPAAWEK

Download         Length: 282 bp

>AT85977 NZ_CP023737:452962-453243 [Methylosinus trichosporium OB3b]
ATGACTGTCAAACCACAAGCGAAGCGCGACACGCTCAATGTGCGGGTCAAGCCCGAGGATCGCAGCCTCATCGACCGCGC
AGCGCGGCTGCTGGGCAAGAGCCGCGCCGATTTTCTGCTCGAATCTGCGCGGCGGGCGGCGCATGACGTTCTGCTGGATC
AGACGCTCTTCAAAGTCAGTCCACAAGTCTACGGCGAGTTCATCGCGAGGCTCGACGCGCCGCCTGCGCCGAATGAGAGG
CTTCGCCGCACGATGGCGACTCCGGCGGCGTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1A6FSR2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1A6FRN5

References