Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 452962..453734 Replicon chromosome
Accession NZ_CP023737
Organism Methylosinus trichosporium OB3b

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1A6FSR2
Locus tag CQW49_RS02160 Protein ID WP_065083547.1
Coordinates 453240..453734 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1A6FRN5
Locus tag CQW49_RS02155 Protein ID WP_003609827.1
Coordinates 452962..453243 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CQW49_RS24270 448798..448977 + 180 WP_155931222.1 hypothetical protein -
CQW49_RS02145 449008..451353 - 2346 WP_003609830.1 TonB-dependent receptor -
CQW49_RS02150 451549..452844 - 1296 WP_003609828.1 dihydroorotase -
CQW49_RS02155 452962..453243 + 282 WP_003609827.1 DUF1778 domain-containing protein Antitoxin
CQW49_RS02160 453240..453734 + 495 WP_065083547.1 GNAT family N-acetyltransferase Toxin
CQW49_RS02165 453781..454119 - 339 WP_024749350.1 septum formation initiator family protein -
CQW49_RS02170 454227..457817 - 3591 WP_099831727.1 hypothetical protein -
CQW49_RS02175 457971..458429 + 459 WP_024749349.1 peroxiredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(37-141)

Antitoxin

Vibrio phage ICP1, Orf50

(3-93)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17593.28 Da        Isoelectric Point: 6.8716

>T85977 WP_065083547.1 NZ_CP023737:453240-453734 [Methylosinus trichosporium OB3b]
MTLTAPEPIDESHIVNDFDSGVPVLDDWLMRRARANQASGASRAYVICEDRRVVGYYALAAGAVEISNATGRLRRNMPDP
VPIAVLGRLAIHRGFQGNGLGRALVRDAGQRVLQAADIIGIRGILVHVLSPEAEAFYHALGLEASALQPMTLMATLADLR
AALI

Download         Length: 495 bp

>T85977 NZ_CP023737:453240-453734 [Methylosinus trichosporium OB3b]
ATGACGCTCACTGCTCCCGAGCCGATCGATGAATCGCACATCGTCAATGACTTCGACTCTGGCGTTCCGGTCCTCGACGA
TTGGCTGATGCGCCGCGCCCGGGCGAACCAGGCGAGCGGCGCATCGCGCGCATATGTGATTTGCGAGGACCGGCGTGTCG
TCGGCTATTATGCGCTCGCCGCCGGCGCCGTCGAAATCTCGAATGCGACAGGACGCCTTCGCCGCAACATGCCCGATCCT
GTCCCGATCGCCGTGCTGGGACGATTGGCGATCCACCGCGGCTTCCAGGGAAACGGCCTCGGTCGCGCTCTCGTGCGGGA
CGCGGGGCAGCGTGTGCTGCAAGCCGCCGATATTATAGGGATTCGTGGAATTCTCGTTCACGTGCTCTCACCGGAAGCAG
AGGCTTTTTATCACGCCCTCGGCCTAGAGGCGTCGGCCTTGCAGCCCATGACGCTGATGGCGACGTTGGCCGATCTGCGC
GCAGCGTTGATTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10553.20 Da        Isoelectric Point: 11.0151

>AT85977 WP_003609827.1 NZ_CP023737:452962-453243 [Methylosinus trichosporium OB3b]
MTVKPQAKRDTLNVRVKPEDRSLIDRAARLLGKSRADFLLESARRAAHDVLLDQTLFKVSPQVYGEFIARLDAPPAPNER
LRRTMATPAAWEK

Download         Length: 282 bp

>AT85977 NZ_CP023737:452962-453243 [Methylosinus trichosporium OB3b]
ATGACTGTCAAACCACAAGCGAAGCGCGACACGCTCAATGTGCGGGTCAAGCCCGAGGATCGCAGCCTCATCGACCGCGC
AGCGCGGCTGCTGGGCAAGAGCCGCGCCGATTTTCTGCTCGAATCTGCGCGGCGGGCGGCGCATGACGTTCTGCTGGATC
AGACGCTCTTCAAAGTCAGTCCACAAGTCTACGGCGAGTTCATCGCGAGGCTCGACGCGCCGCCTGCGCCGAATGAGAGG
CTTCGCCGCACGATGGCGACTCCGGCGGCGTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A6FSR2

Antitoxin

Source ID Structure
AlphaFold DB A0A1A6FRN5

References