Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1217953..1218469 Replicon chromosome
Accession NZ_CP023722
Organism Klebsiella pneumoniae strain TVGHCRE225

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CO233_RS06220 Protein ID WP_002886902.1
Coordinates 1218185..1218469 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CO233_RS06215 Protein ID WP_002886901.1
Coordinates 1217953..1218195 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO233_RS06200 1213982..1214722 + 741 WP_002886899.1 KDGP aldolase family protein -
CO233_RS06205 1214788..1215942 + 1155 WP_002886900.1 lactonase family protein -
CO233_RS06210 1215965..1217875 + 1911 WP_004152270.1 BglG family transcription antiterminator -
CO233_RS06215 1217953..1218195 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CO233_RS06220 1218185..1218469 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO233_RS06225 1218473..1218937 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CO233_RS06230 1219178..1221316 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CO233_RS06235 1221673..1222416 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CO233_RS32050 1222419..1222592 - 174 WP_002886906.1 hypothetical protein -
CO233_RS06240 1222677..1222985 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T85945 WP_002886902.1 NZ_CP023722:1218185-1218469 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T85945 NZ_CP023722:1218185-1218469 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT85945 WP_002886901.1 NZ_CP023722:1217953-1218195 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT85945 NZ_CP023722:1217953-1218195 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References