Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4626663..4627228 Replicon chromosome
Accession NZ_CP023714
Organism Rhodococcus ruber strain YC-YT1

Toxin (Protein)


Gene name mazF Uniprot ID A0A385HTA4
Locus tag YT1_RS22070 Protein ID WP_010593326.1
Coordinates 4626663..4627019 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A385HSN3
Locus tag YT1_RS22075 Protein ID WP_010593327.1
Coordinates 4627016..4627228 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YT1_RS22045 4622877..4623374 - 498 WP_119700016.1 hypothetical protein -
YT1_RS22050 4623738..4624796 - 1059 WP_010593322.1 mannan endo-1,4-beta-mannosidase -
YT1_RS22055 4624983..4625231 + 249 WP_029539937.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
YT1_RS22060 4625228..4625608 + 381 WP_043804893.1 type II toxin-antitoxin system VapC family toxin -
YT1_RS22065 4625761..4626600 + 840 WP_119700017.1 hypothetical protein -
YT1_RS22070 4626663..4627019 - 357 WP_010593326.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
YT1_RS22075 4627016..4627228 - 213 WP_010593327.1 ribbon-helix-helix protein, CopG family Antitoxin
YT1_RS22080 4627439..4628020 + 582 WP_010593328.1 GNAT family N-acetyltransferase -
YT1_RS22085 4628028..4628423 - 396 Protein_4169 hypothetical protein -
YT1_RS22090 4628547..4629830 + 1284 WP_029539938.1 competence/damage-inducible protein A -
YT1_RS22095 4630275..4631186 + 912 WP_029539939.1 formylglycine-generating enzyme family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12867.56 Da        Isoelectric Point: 7.3229

>T85936 WP_010593326.1 NZ_CP023714:c4627019-4626663 [Rhodococcus ruber]
MIRRAQIHWVDPDPAQGSEAAERRPAVVVSNDRANATAENLGRGVVTVVPLTTNTSHVFPFQVLVEPDESGLTRAAKAQA
EQVRSVSVRRLDTEPVGRLGARTLAALEEALRLHLDLR

Download         Length: 357 bp

>T85936 NZ_CP023714:c4627019-4626663 [Rhodococcus ruber]
ATGATCCGCCGAGCGCAGATCCACTGGGTCGATCCGGACCCGGCGCAGGGTAGCGAAGCGGCCGAGCGCCGGCCGGCAGT
GGTCGTGAGCAACGACCGCGCCAACGCGACCGCCGAGAATCTGGGCAGAGGAGTGGTCACCGTCGTTCCTCTGACCACCA
ACACCTCACACGTCTTTCCGTTCCAGGTACTCGTGGAACCCGACGAGTCAGGGCTGACCAGAGCAGCGAAAGCTCAGGCA
GAACAGGTACGTTCGGTGTCCGTGCGTCGCCTGGACACCGAACCTGTCGGAAGGCTCGGGGCGAGAACTCTCGCAGCGCT
CGAGGAAGCGCTGCGGCTACATCTCGATTTGCGTTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7652.40 Da        Isoelectric Point: 4.1694

>AT85936 WP_010593327.1 NZ_CP023714:c4627228-4627016 [Rhodococcus ruber]
MTVKFTISLPDEDAHVLDEYIRDHGLRGRSAGVRAAVRLLAAAGLERDYATAFAEVDTDDAWDVTTADTE

Download         Length: 213 bp

>AT85936 NZ_CP023714:c4627228-4627016 [Rhodococcus ruber]
ATGACCGTCAAGTTCACGATCAGCCTCCCGGACGAGGATGCCCACGTCCTCGACGAGTACATCCGGGATCATGGGCTCCG
CGGCCGGTCGGCGGGAGTCCGGGCCGCTGTCCGCCTGCTCGCGGCAGCCGGACTCGAACGGGACTACGCCACAGCCTTTG
CCGAGGTCGACACAGACGACGCGTGGGATGTCACCACGGCCGACACCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A385HTA4

Antitoxin

Source ID Structure
AlphaFold DB A0A385HSN3

References