85916

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 633739..634375 Replicon chromosome
Accession NZ_CP023704
Organism Caldibacillus thermoamylovorans strain SSBM

Toxin (Protein)


Gene name pemK Uniprot ID A0A090IRX6
Locus tag CQJ30_RS03155 Protein ID WP_034767829.1
Coordinates 634025..634375 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A090IQT1
Locus tag CQJ30_RS03150 Protein ID WP_034767827.1
Coordinates 633739..634020 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CQJ30_RS03130 629618..630199 - 582 WP_041902696.1 rhomboid family intramembrane serine protease -
CQJ30_RS03135 630286..630642 + 357 WP_041847512.1 holo-ACP synthase -
CQJ30_RS19545 630948..631085 + 138 WP_161522345.1 hypothetical protein -
CQJ30_RS19550 631042..631194 + 153 WP_161522346.1 hypothetical protein -
CQJ30_RS03140 631282..631704 - 423 WP_108897481.1 hypothetical protein -
CQJ30_RS19240 631770..632012 + 243 WP_152032322.1 hypothetical protein -
CQJ30_RS03145 632191..633216 + 1026 WP_095142674.1 outer membrane lipoprotein carrier protein LolA -
CQJ30_RS03150 633739..634020 + 282 WP_034767827.1 hypothetical protein Antitoxin
CQJ30_RS03155 634025..634375 + 351 WP_034767829.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CQJ30_RS03160 634788..636980 + 2193 WP_192878697.1 RNA-binding transcriptional accessory protein -
CQJ30_RS03165 637217..637330 - 114 WP_095142672.1 cortex morphogenetic protein CmpA -
CQJ30_RS03170 637590..638051 + 462 WP_041846809.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13018.13 Da        Isoelectric Point: 4.9105

>T85916 WP_034767829.1 NZ_CP023704:634025-634375 [Caldibacillus thermoamylovorans]
MIVKRGDVFFADLSPVVGSEQGGVRPVLILQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEEMMEKVDEALQISLGLIEF

Download         Length: 351 bp

>T85916 NZ_CP023704:634025-634375 [Caldibacillus thermoamylovorans]
TTGATTGTTAAACGAGGCGACGTTTTCTTTGCCGACCTTTCCCCTGTCGTTGGTTCAGAACAAGGAGGCGTCCGTCCTGT
TCTCATATTACAGAATGACATAGGGAATCGGTTCAGTCCAACTGTGATTATCGCAGCGATCACCGCTCAGATTCAAAAGG
CAAAATTACCTACACATGTGGAAATCGATGCGAAAAAATACGGCTTTGAACGAGACTCGGTTATACTTCTAGAACAAATT
CGGACAATTGATAAACAGCGACTTACCGATAAAATTACCCATCTGGATGAAGAAATGATGGAAAAAGTTGATGAGGCGTT
ACAAATCAGTTTAGGATTGATCGAATTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10821.33 Da        Isoelectric Point: 5.7499

>AT85916 WP_034767827.1 NZ_CP023704:633739-634020 [Caldibacillus thermoamylovorans]
VSESSATQEILVNLPQSLLLEMDGFIKQENVNRDELIYQATKMFLRERKKRHIRESMRRGYMEMAKINLTIASESFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp

>AT85916 NZ_CP023704:633739-634020 [Caldibacillus thermoamylovorans]
GTGTCTGAATCCAGCGCAACACAAGAAATACTAGTGAACTTGCCGCAAAGTCTATTACTGGAAATGGATGGATTTATTAA
ACAAGAAAATGTGAATCGCGATGAGCTGATTTATCAAGCGACAAAAATGTTTTTACGTGAAAGGAAAAAAAGACACATTC
GAGAATCCATGAGACGGGGATATATGGAAATGGCCAAAATTAATTTGACTATTGCATCGGAAAGCTTTCAGGCTGAATAT
GAGGCAGAACATACAGTTGAGAGACTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090IRX6

Antitoxin

Source ID Structure
AlphaFold DB A0A090IQT1

References