Detailed information of TA system TA085914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 5377572..5378113
• Replicon: chromosome
• Accession: NZ_CP023702
• Organism: Streptomyces nitrosporeus strain ATCC 12769

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CP967_RS23710
• Protein ID: WP_150489908.1
• Coordinates: 5377572..5377835 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CP967_RS23715
• Protein ID: WP_167535425.1
• Coordinates: 5377832..5378113 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP967_RS23680	5372898..5374631	-	1734	WP_150489905.1	ABC transporter ATP-binding protein/permease	-
CP967_RS23685	5374803..5376248	-	1446	WP_150489906.1	sugar kinase	-
CP967_RS23690	5376363..5376674	-	312	WP_150489907.1	YtxH domain-containing protein	-
CP967_RS23710	5377572..5377835	-	264	WP_150489908.1	Txe/YoeB family addiction module toxin	Toxin
CP967_RS23715	5377832..5378113	-	282	WP_167535425.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CP967_RS23720	5378681..5379622	+	942	WP_167535426.1	hypothetical protein	-
CP967_RS23725	5379562..5380755	-	1194	WP_150489911.1	hypothetical protein	-
CP967_RS23730	5381162..5382427	+	1266	WP_150489912.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10381.69 Da
• Isoelectric Point: 8.0487

>T85914 WP_150489908.1 NZ_CP023702:c5377835-5377572 [Streptomyces nitrosporeus]
VKALFLDDSWNDYLWWQGNDRKILKRVNQLIADIDRGGNEGIGKPEPLRNDLSGYWSRRINSEHRLVYRIDENGIIHVVA
CRFHYER

Nucleotide

• Length: 264 bp

>T85914 NZ_CP023702:c5377835-5377572 [Streptomyces nitrosporeus]
GTGAAGGCGCTGTTCCTCGACGACAGCTGGAACGATTACCTGTGGTGGCAGGGGAACGACCGCAAAATACTGAAGCGCGT
CAACCAGCTGATCGCCGACATCGACCGGGGCGGCAACGAAGGGATCGGCAAGCCCGAACCGCTGCGGAACGACCTCTCCG
GCTACTGGTCGCGGCGGATCAACTCCGAACACCGACTGGTGTACCGCATCGATGAGAACGGCATCATCCACGTGGTGGCG
TGCCGCTTCCACTACGAACGGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10112.32 Da
• Isoelectric Point: 4.2158

>AT85914 WP_167535425.1 NZ_CP023702:c5378113-5377832 [Streptomyces nitrosporeus]
MKTMSVTELRAGLADALDAVENDAEELVITRAGHEPMVIVSLAEYEALKETDYLLRSPAMAERLRRSIEQDRAGQGALRE
LADPDDEAGRGAA

Nucleotide

• Length: 282 bp

>AT85914 NZ_CP023702:c5378113-5377832 [Streptomyces nitrosporeus]
ATGAAGACGATGAGTGTCACCGAGCTACGCGCGGGCCTCGCCGACGCCCTCGACGCGGTGGAGAACGACGCCGAGGAGCT
GGTCATCACCCGGGCCGGCCATGAGCCCATGGTCATCGTCTCGCTCGCCGAGTACGAGGCACTGAAAGAGACCGACTACC
TGCTGCGGTCGCCCGCGATGGCCGAGCGCCTGCGCAGGTCCATCGAGCAGGACCGGGCCGGCCAGGGCGCGCTCCGCGAG
TTGGCGGATCCCGATGACGAGGCCGGGCGGGGCGCCGCGTGA