Detailed information of TA system TA085913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2890756..2891281
• Replicon: chromosome
• Accession: NZ_CP023701
• Organism: Streptomyces subrutilus strain ATCC 27467

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CP968_RS12320
• Protein ID: WP_150518057.1
• Coordinates: 2891018..2891281 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5UWF1
• Locus tag: CP968_RS12315
• Protein ID: WP_019434848.1
• Coordinates: 2890756..2891025 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP968_RS12305	2886436..2887485	-	1050	WP_150521879.1	esterase family protein	-
CP968_RS12310	2887888..2890155	-	2268	WP_150518056.1	DEAD/DEAH box helicase	-
CP968_RS12315	2890756..2891025	+	270	WP_019434848.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CP968_RS12320	2891018..2891281	+	264	WP_150518057.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP968_RS12325	2891417..2892505	-	1089	WP_150518058.1	redox-regulated ATPase YchF	-
CP968_RS12330	2892730..2893161	+	432	WP_189828958.1	hypothetical protein	-
CP968_RS12335	2893375..2894118	-	744	WP_208835986.1	ROK family protein	-
CP968_RS12340	2894134..2895138	-	1005	WP_189828955.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10028.43 Da
• Isoelectric Point: 8.5042

>T85913 WP_150518057.1 NZ_CP023701:2891018-2891281 [Streptomyces subrutilus]
VSEYRTAFRPEAQAELRKIPRDMALRILAKLTELETDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTGYET

Nucleotide

• Length: 264 bp

>T85913 NZ_CP023701:2891018-2891281 [Streptomyces subrutilus]
GTGAGTGAGTACCGAACCGCCTTCCGCCCCGAGGCGCAGGCCGAGCTTCGGAAGATCCCTCGCGACATGGCACTGCGCAT
CCTGGCCAAGCTGACCGAGCTGGAGACCGACCCCCTCGGCTTCAACACCACCGCACTCGTGTCCCAGCCCGAGCGGCGCC
GTCTGCGCGTCGGCGACTACCGCGTCGTCTACACGATCGACAACGGGGAGCTGGTGGTCTGGGTCGTTCATGTGGGACAC
CGGTCCACCGGTTATGAGACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10259.71 Da
• Isoelectric Point: 4.6265

>AT85913 WP_019434848.1 NZ_CP023701:2890756-2891025 [Streptomyces subrutilus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT85913 NZ_CP023701:2890756-2891025 [Streptomyces subrutilus]
ATGACGCAGCCGCTGCCCATAGAGTCCATCCGCGACGTGCGCGCCCACCTGGCGGAAGTCGTGGAGCGTGCGGACCGCGA
CGACGTACCAACGGTCATCACCCGCCGGGGCAAGGAAGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCACCGGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Structures

Antitoxin

• AlphaFold DB: S5UWF1