Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2955304..2955869 Replicon chromosome
Accession NZ_CP023693
Organism Streptomyces cinereoruber strain ATCC 19740

Toxin (Protein)


Gene name doc Uniprot ID A0A150VZH6
Locus tag CP977_RS13100 Protein ID WP_030210020.1
Coordinates 2955304..2955675 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A150VZG3
Locus tag CP977_RS13105 Protein ID WP_062755237.1
Coordinates 2955672..2955869 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP977_RS13085 2951312..2952106 - 795 WP_062755239.1 hypothetical protein -
CP977_RS13090 2952350..2952991 - 642 WP_030210027.1 helix-turn-helix domain-containing protein -
CP977_RS13095 2953388..2955184 - 1797 WP_062757066.1 DEAD/DEAH box helicase -
CP977_RS13100 2955304..2955675 - 372 WP_030210020.1 Fic family protein Toxin
CP977_RS13105 2955672..2955869 - 198 WP_062755237.1 Arc family DNA-binding protein Antitoxin
CP977_RS13110 2955902..2957407 - 1506 WP_152370143.1 MFS transporter -
CP977_RS13120 2957810..2958127 + 318 WP_152370144.1 hypothetical protein -
CP977_RS13125 2958384..2959316 + 933 WP_152370145.1 serine/threonine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(11-81)

Antitoxin

Arc-like DNA binding domain

(5-39)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13647.47 Da        Isoelectric Point: 4.6142

>T85907 WP_030210020.1 NZ_CP023693:c2955675-2955304 [Streptomyces cinereoruber]
VTYYLTLPEVLNLAQRLGADEVRDYGLLDSALARPQSSVFGQDAYPDVWQKAAALMESLARNHGLVDGNKRIAWYATWVF
LHMNGHPLDSAFDVDEAEAFVLDVCQGALDVPKIAAQLPRFAR

Download         Length: 372 bp

>T85907 NZ_CP023693:c2955675-2955304 [Streptomyces cinereoruber]
GTGACGTACTACCTCACGCTCCCCGAGGTCCTGAACCTCGCGCAGCGGCTCGGCGCGGACGAGGTGCGGGACTACGGTCT
CCTCGACTCCGCCCTGGCACGTCCGCAGTCGAGCGTGTTCGGCCAGGACGCCTACCCGGACGTCTGGCAGAAGGCCGCGG
CGCTCATGGAATCGCTCGCCCGCAACCACGGACTCGTGGACGGGAACAAGCGCATCGCCTGGTACGCGACCTGGGTCTTC
CTCCACATGAACGGACACCCACTGGACTCGGCCTTCGACGTCGACGAGGCGGAGGCGTTCGTCCTGGACGTCTGCCAGGG
CGCCCTCGACGTCCCCAAGATCGCCGCGCAGCTGCCCCGGTTCGCGCGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7436.28 Da        Isoelectric Point: 4.8377

>AT85907 WP_062755237.1 NZ_CP023693:c2955869-2955672 [Streptomyces cinereoruber]
MAGLNVRFTEEELDALRERAEAEGRSMQSFAHDAVIRAINEHSRLFDEAAEHVLKVSEELNRRLA

Download         Length: 198 bp

>AT85907 NZ_CP023693:c2955869-2955672 [Streptomyces cinereoruber]
ATGGCTGGTCTCAACGTCAGGTTCACCGAAGAAGAGCTGGACGCCCTGCGCGAGCGGGCCGAGGCGGAGGGGCGCAGCAT
GCAGTCCTTCGCGCACGACGCCGTGATCCGGGCCATAAACGAGCACTCCCGCCTCTTCGACGAGGCGGCCGAGCACGTGC
TGAAGGTCAGTGAGGAGCTGAACCGGAGGCTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A150VZH6

Antitoxin

Source ID Structure
AlphaFold DB A0A150VZG3

References