Detailed information of TA system TA085906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2793061..2793586
• Replicon: chromosome
• Accession: NZ_CP023692
• Organism: Streptomyces vinaceus strain ATCC 27476

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CP980_RS12215
• Protein ID: WP_132756451.1
• Coordinates: 2793323..2793586 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S2KF24
• Locus tag: CP980_RS12210
• Protein ID: WP_071271322.1
• Coordinates: 2793061..2793330 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP980_RS12195	2788338..2789045	+	708	WP_132756457.1	hypothetical protein	-
CP980_RS12200	2789049..2789513	-	465	WP_150528157.1	hypothetical protein	-
CP980_RS12205	2789506..2792748	-	3243	WP_150528158.1	M36 family metallopeptidase	-
CP980_RS12210	2793061..2793330	+	270	WP_071271322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CP980_RS12215	2793323..2793586	+	264	WP_132756451.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP980_RS12220	2793721..2794809	-	1089	WP_099889686.1	redox-regulated ATPase YchF	-
CP980_RS35085	2794945..2795490	+	546	WP_165937266.1	hypothetical protein	-
CP980_RS12230	2795496..2796242	-	747	WP_132756449.1	ROK family protein	-
CP980_RS12235	2796269..2797273	-	1005	WP_189998493.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10052.48 Da
• Isoelectric Point: 8.5042

>T85906 WP_132756451.1 NZ_CP023692:2793323-2793586 [Streptomyces vinaceus]
VSEYRTVFRPEAQAELRKIPRDVALRILAKLTELESDPLGFNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVYET

Nucleotide

• Length: 264 bp

>T85906 NZ_CP023692:2793323-2793586 [Streptomyces vinaceus]
GTGAGTGAGTACCGGACCGTCTTCCGACCGGAGGCGCAGGCCGAGCTTCGGAAGATCCCTCGCGACGTGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAGCTGGAGAGCGATCCCCTCGGGTTCAACACCACCGCACTCGTGTCGCAGCCGGAACGCCGTC
GGCTGCGAGTCGGCGACTACCGGGTCGTCTACACGATCGACAACGGAGAGCTCGTGGTGTGGGTCGTCCATGTGGGACAC
AGGTCTACCGTTTACGAGACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10245.68 Da
• Isoelectric Point: 4.6265

>AT85906 WP_071271322.1 NZ_CP023692:2793061-2793330 [Streptomyces vinaceus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDV
MRETLARGE

Nucleotide

• Length: 270 bp

>AT85906 NZ_CP023692:2793061-2793330 [Streptomyces vinaceus]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGCGACGTGCGCGCCCACCTGGCGGAAGTCGTGGAGCGTGCGGACCGCGA
CGACGTACCCACGGTCATCACGCGCCGGGGCAAGGAAGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACGTC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1S2KF24