Detailed information of TA system TA085905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 6185986..6186556
• Replicon: chromosome
• Accession: NZ_CP023688
• Organism: Streptomyces rimosus strain ATCC 10970

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: L8ERH5
• Locus tag: CP984_RS26765
• Protein ID: WP_003982453.1
• Coordinates: 6186209..6186556 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: L8ERT3
• Locus tag: CP984_RS26760
• Protein ID: WP_003982452.1
• Coordinates: 6185986..6186222 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP984_RS26745	6181408..6182565	+	1158	WP_003982449.1	allantoicase	-
CP984_RS26750	6182637..6185213	-	2577	WP_003982450.1	aminopeptidase N	-
CP984_RS26755	6185347..6185946	+	600	WP_003982451.1	Uma2 family endonuclease	-
CP984_RS26760	6185986..6186222	+	237	WP_003982452.1	ribbon-helix-helix domain-containing protein	Antitoxin
CP984_RS26765	6186209..6186556	+	348	WP_003982453.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CP984_RS26770	6186637..6187158	+	522	WP_003982454.1	DUF1203 domain-containing protein	-
CP984_RS26775	6187229..6188260	-	1032	WP_003982455.1	aspartate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12493.43 Da
• Isoelectric Point: 10.8691

>T85905 WP_003982453.1 NZ_CP023688:6186209-6186556 [Streptomyces rimosus]
MRRGDLYLVDLEPVRGSEANKYRPAVVVSNDAANRSVQRAGRGVVTVVPVTANVARVYPFQVLLTADDCGLPRDSKAQCE
QVRAVSVERLGRRVGSVPARVMVGLDAALRRHLAL

Nucleotide

• Length: 348 bp

>T85905 NZ_CP023688:6186209-6186556 [Streptomyces rimosus]
ATGCGGCGCGGTGACCTCTATCTGGTTGATCTGGAGCCGGTCCGGGGGAGCGAGGCCAACAAGTACCGTCCTGCGGTGGT
CGTGTCCAACGACGCGGCCAATCGGTCCGTGCAGCGCGCCGGAAGGGGTGTGGTGACGGTCGTGCCTGTGACGGCCAACG
TCGCCCGGGTCTACCCGTTCCAGGTGCTGCTGACCGCCGACGACTGCGGGCTGCCGCGCGACTCGAAGGCCCAGTGCGAG
CAGGTGCGCGCGGTGTCCGTCGAGCGGCTGGGGCGGCGGGTCGGCAGCGTCCCGGCGCGCGTGATGGTTGGGCTGGACGC
GGCCCTGCGCAGGCATCTGGCGCTCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8374.07 Da
• Isoelectric Point: 3.7856

>AT85905 WP_003982452.1 NZ_CP023688:6185986-6186222 [Streptomyces rimosus]
MKISVSLPEEDIAFLDAYGKKTDADSRSAVIHAAVELLRASELEADYASAWEEWDESDDALLWDGVSGDGIGSADAAR

Nucleotide

• Length: 237 bp

>AT85905 NZ_CP023688:6185986-6186222 [Streptomyces rimosus]
ATGAAGATCAGCGTCAGCCTGCCGGAAGAGGACATCGCCTTCCTCGACGCGTACGGCAAGAAGACGGACGCCGATTCGCG
GTCGGCGGTGATCCACGCGGCGGTCGAGCTGCTGCGTGCCTCCGAGCTGGAGGCGGATTACGCCTCGGCGTGGGAGGAGT
GGGACGAGAGCGACGACGCGCTGCTGTGGGACGGGGTCTCCGGGGACGGGATCGGAAGCGCCGATGCGGCGCGGTGA

Structures

Toxin

• AlphaFold DB: L8ERH5

Antitoxin

• AlphaFold DB: L8ERT3