Detailed information of TA system TA085904

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3425629..3426154
• Replicon: chromosome
• Accession: NZ_CP023688
• Organism: Streptomyces rimosus strain ATCC 10970

Toxin (Protein)

• Gene name: relE
• Uniprot ID: L8EGB8
• Locus tag: CP984_RS14005
• Protein ID: WP_003987428.1
• Coordinates: 3425891..3426154 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: L8ED57
• Locus tag: CP984_RS14000
• Protein ID: WP_003987429.1
• Coordinates: 3425629..3425898 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP984_RS13975	3420662..3421384	+	723	WP_030181983.1	PIG-L family deacetylase	-
CP984_RS13980	3421372..3422340	-	969	WP_003982326.1	alpha/beta hydrolase	-
CP984_RS13985	3422470..3422979	+	510	WP_003982327.1	hypothetical protein	-
CP984_RS13990	3423020..3423604	+	585	WP_003982328.1	Uma2 family endonuclease	-
CP984_RS13995	3423646..3425325	-	1680	WP_076611972.1	IS1182-like element ISSdi1 family transposase	-
CP984_RS14000	3425629..3425898	+	270	WP_003987429.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CP984_RS14005	3425891..3426154	+	264	WP_003987428.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP984_RS14010	3426289..3427377	-	1089	WP_003987427.1	redox-regulated ATPase YchF	-
CP984_RS14015	3427920..3428627	+	708	WP_063604328.1	hypothetical protein	-
CP984_RS14020	3428593..3429465	-	873	WP_078586864.1	ROK family protein	-
CP984_RS14025	3429551..3430594	-	1044	WP_078586862.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3423646..3425325	1679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-56)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10084.54 Da
• Isoelectric Point: 8.5041

>T85904 WP_003987428.1 NZ_CP023688:3425891-3426154 [Streptomyces rimosus]
VSEYRTVFRPEAQTELRKVPRDMALRILAKLTELETDPLGFNTTALVSQPDRRRLRVGDYRLIYTIDNGELVVWVVHVGH
RSTVYDA

Nucleotide

• Length: 264 bp

>T85904 NZ_CP023688:3425891-3426154 [Streptomyces rimosus]
GTGAGTGAGTACCGCACCGTCTTCCGCCCCGAGGCTCAGACCGAACTCCGCAAGGTCCCGCGAGACATGGCTCTCCGCAT
TCTGGCGAAGCTGACCGAGTTGGAGACCGACCCGCTGGGGTTCAACACCACCGCCCTCGTCTCCCAGCCCGACCGCCGAC
GCCTACGAGTGGGTGACTACCGCCTGATCTACACGATCGACAACGGCGAGCTGGTGGTGTGGGTGGTACACGTCGGGCAT
CGCTCCACCGTCTACGACGCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10290.73 Da
• Isoelectric Point: 4.7473

>AT85904 WP_003987429.1 NZ_CP023688:3425629-3425898 [Streptomyces rimosus]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIETLRKYQEWEEREINRIIDERMANPAPGIPLEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT85904 NZ_CP023688:3425629-3425898 [Streptomyces rimosus]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGCGATGTCCGGGCGCATCTGGCCGAGGTCGTTGAGCGAGCCGACCGGGA
CGACGTACCCACCGTGATCACCCGACGCGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGACGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGATGAGCGCATGGCCAACCCTGCACCCGGCATCCCGCTCGAGGACATC
ATGAGGGAGACGCTGGCACGCAGTGAGTGA

Structures

Toxin

• AlphaFold DB: L8EGB8

Antitoxin

• AlphaFold DB: L8ED57