Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3920035..3920668 Replicon chromosome
Accession NZ_CP023687
Organism Acidovorax citrulli strain KACC17005

Toxin (Protein)


Gene name vapC Uniprot ID A1TJP6
Locus tag CQB05_RS17925 Protein ID WP_011793755.1
Coordinates 3920035..3920448 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B0DRJ9
Locus tag CQB05_RS17930 Protein ID WP_041827216.1
Coordinates 3920435..3920668 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CQB05_RS17900 3915042..3916079 - 1038 WP_011793760.1 anthranilate phosphoribosyltransferase -
CQB05_RS17905 3916112..3916795 - 684 WP_011793759.1 LysE family translocator -
CQB05_RS17910 3916867..3917439 - 573 WP_011793758.1 aminodeoxychorismate/anthranilate synthase component II -
CQB05_RS17915 3918124..3919638 + 1515 WP_011793757.1 conjugal transfer protein TraG N-terminal domain-containing protein -
CQB05_RS17920 3919652..3920014 - 363 WP_011793756.1 DUF3742 family protein -
CQB05_RS17925 3920035..3920448 - 414 WP_011793755.1 PIN domain-containing protein Toxin
CQB05_RS17930 3920435..3920668 - 234 WP_041827216.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3876069..4045265 169196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15147.48 Da        Isoelectric Point: 6.2136

>T85903 WP_011793755.1 NZ_CP023687:c3920448-3920035 [Acidovorax citrulli]
MAAGKGKVFLDSNVVLYLLSEDAAKADSAEALLHRRPVISVQVLNEVTHVCVRKLKMGWGEVGQFLALVREFCSIVPLTV
EVHDRARQLAERHQLSFYDACIVAAAAAEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Download         Length: 414 bp

>T85903 NZ_CP023687:c3920448-3920035 [Acidovorax citrulli]
ATGGCCGCGGGTAAGGGCAAGGTGTTCCTCGACAGCAACGTGGTGCTCTACCTGCTGTCCGAGGACGCGGCGAAGGCGGA
CAGCGCCGAGGCGCTGCTGCATCGTCGCCCGGTCATCAGCGTCCAGGTACTCAACGAGGTCACCCACGTCTGCGTGCGCA
AGCTGAAGATGGGGTGGGGAGAGGTGGGTCAGTTCCTGGCGCTGGTGAGAGAGTTCTGCAGCATTGTTCCGCTCACAGTC
GAGGTGCACGACCGGGCCCGCCAACTGGCCGAGCGGCACCAGCTGTCGTTCTACGACGCATGCATTGTGGCGGCCGCCGC
AGCCGAAGGCTGCCAGACGCTCTACTCCGAAGACATGCACCATGGCCTCATCATCGAAGAGAGCCTGTCGATTCGTAACC
CGTTCAACGTTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8518.76 Da        Isoelectric Point: 8.7857

>AT85903 WP_041827216.1 NZ_CP023687:c3920668-3920435 [Acidovorax citrulli]
MLVAKWGNSLAVRLPANVVEALELREGDDIEIFVGDARSFAVSKKPGAEAMLERLRTFRGKLPADFKFNRDEANGRG

Download         Length: 234 bp

>AT85903 NZ_CP023687:c3920668-3920435 [Acidovorax citrulli]
ATGCTAGTCGCGAAGTGGGGCAATAGCTTGGCGGTTCGCCTGCCGGCGAACGTAGTCGAAGCGCTCGAACTGCGGGAAGG
CGATGACATCGAAATCTTCGTCGGTGATGCGCGATCGTTCGCGGTGAGCAAGAAGCCCGGCGCCGAGGCGATGCTGGAGC
GCCTCCGTACCTTCCGCGGCAAGCTGCCGGCGGACTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1TJP6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0DRJ9

References