Detailed information of TA system TA085900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 24344..24836
• Replicon: plasmid pZM33
• Accession: NZ_CP023684
• Organism: Zymomonas mobilis subsp. mobilis strain ZM4 substr. 8b

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: ZMO3_RS09485
• Protein ID: WP_062339561.1
• Coordinates: 24344..24628 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: ZMO3_RS09490
• Protein ID: WP_062339563.1
• Coordinates: 24612..24836 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ZMO3_RS09475	22216..23288	-	1073	Protein_23	IS701 family transposase	-
ZMO3_RS09480	23442..24139	+	698	Protein_24	IS5 family transposase	-
ZMO3_RS09485	24344..24628	-	285	WP_062339561.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ZMO3_RS09490	24612..24836	-	225	WP_062339563.1	TraY domain-containing protein	Antitoxin
ZMO3_RS09495	25179..26684	-	1506	WP_062339565.1	helix-turn-helix domain-containing protein	-
ZMO3_RS09500	26791..27042	-	252	WP_062339567.1	DUF2312 domain-containing protein	-
ZMO3_RS09505	27167..27484	-	318	WP_062339569.1	hypothetical protein	-
ZMO3_RS09510	27888..28376	+	489	WP_062339571.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..33006	33006

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10895.82 Da
• Isoelectric Point: 10.9192

>T85900 WP_062339561.1 NZ_CP023684:c24628-24344 [Zymomonas mobilis subsp. mobilis]
MAWKIEFDPAAQKELKKLGTQPAKRILRFLSERLALADDPRSFGAALKGTTLGNLWKYRIGDYRIIADIEDNVMRILVVR
IGNRREIYKKAVRH

Nucleotide

• Length: 285 bp

>T85900 NZ_CP023684:c24628-24344 [Zymomonas mobilis subsp. mobilis]
ATGGCTTGGAAAATTGAATTCGATCCAGCCGCGCAAAAAGAGTTGAAAAAATTAGGAACACAGCCAGCTAAGCGGATCTT
AAGATTTTTATCTGAACGATTGGCCTTGGCTGATGACCCAAGGTCATTTGGGGCAGCTTTAAAGGGAACAACACTAGGTA
ATTTATGGAAGTATCGAATTGGTGATTACCGCATCATTGCAGATATTGAAGATAATGTGATGCGGATTTTGGTTGTCCGA
ATTGGTAATAGAAGAGAAATTTATAAAAAAGCCGTCAGGCATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8398.60 Da
• Isoelectric Point: 4.8172

>AT85900 WP_062339563.1 NZ_CP023684:c24836-24612 [Zymomonas mobilis subsp. mobilis]
MLAIRLPEEIEDRLSALANATGRTKTFYAREAILHHLEELEDIYLAEARAVKIRSGQTKTVPLENIMAEYGLEN

Nucleotide

• Length: 225 bp

>AT85900 NZ_CP023684:c24836-24612 [Zymomonas mobilis subsp. mobilis]
ATGTTAGCGATCAGACTACCAGAAGAAATAGAAGACCGTTTAAGTGCATTAGCCAATGCAACAGGTAGAACTAAGACTTT
CTATGCCAGAGAAGCCATACTTCATCATTTGGAAGAGCTTGAGGATATTTATCTAGCAGAAGCGCGCGCAGTTAAAATCC
GTTCCGGCCAGACTAAGACTGTCCCATTAGAAAATATTATGGCCGAATATGGCTTGGAAAATTGA