Detailed information of TA system TA085880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3113747..3114225
• Replicon: chromosome
• Accession: NZ_CP023673
• Organism: Escherichia coli strain SMN013SH2

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: CP957_RS17230
• Protein ID: WP_001303876.1
• Coordinates: 3113938..3114225 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: CP957_RS17225
• Protein ID: WP_000536233.1
• Coordinates: 3113747..3113938 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP957_RS17175	3108783..3109061	+	279	WP_074433979.1	hypothetical protein	-
CP957_RS17180	3109063..3110112	+	1050	WP_001265133.1	DUF968 domain-containing protein	-
CP957_RS17185	3110125..3110496	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
CP957_RS17190	3110486..3110857	+	372	WP_000090265.1	antitermination protein	-
CP957_RS17195	3111009..3111827	+	819	WP_000265267.1	CPBP family intramembrane metalloprotease	-
CP957_RS17200	3112114..3112311	+	198	WP_000917737.1	hypothetical protein	-
CP957_RS29410	3112446..3112871	+	426	WP_176465538.1	hypothetical protein	-
CP957_RS17210	3112858..3112953	-	96	Protein_3160	Rha family transcriptional regulator	-
CP957_RS17215	3112937..3113209	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
CP957_RS17220	3113318..3113719	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
CP957_RS17225	3113747..3113938	+	192	WP_000536233.1	hypothetical protein	Antitoxin
CP957_RS17230	3113938..3114225	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CP957_RS17235	3114502..3114657	+	156	WP_000379575.1	DUF1391 family protein	-
CP957_RS17245	3114799..3115188	+	390	WP_032205089.1	hypothetical protein	-
CP957_RS17250	3115375..3115560	-	186	WP_032205087.1	hypothetical protein	-
CP957_RS17260	3116134..3116322	+	189	WP_000413705.1	cell division inhibition protein DicB	-
CP957_RS17265	3116319..3116510	+	192	WP_001098307.1	DUF1482 family protein	-
CP957_RS17270	3116604..3119054	+	2451	WP_009448824.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	ompA	3105476..3142223	36747

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T85880 WP_001303876.1 NZ_CP023673:3113938-3114225 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T85880 NZ_CP023673:3113938-3114225 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT85880 WP_000536233.1 NZ_CP023673:3113747-3113938 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT85880 NZ_CP023673:3113747-3113938 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA