Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1741649..1742285 Replicon chromosome
Accession NZ_CP023666
Organism Bacillus paralicheniformis strain Bac48

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag CP942_RS08790 Protein ID WP_003179128.1
Coordinates 1741649..1741999 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag CP942_RS08795 Protein ID WP_006638778.1
Coordinates 1742004..1742285 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP942_RS08750 1736693..1737292 - 600 WP_035337155.1 SpoIIE family protein phosphatase -
CP942_RS08755 1737289..1738080 - 792 WP_105980536.1 RNA polymerase sigma factor SigB -
CP942_RS08760 1738046..1738528 - 483 WP_020450263.1 anti-sigma B factor RsbW -
CP942_RS08765 1738528..1738854 - 327 WP_020450262.1 anti-sigma factor antagonist -
CP942_RS08770 1738913..1739920 - 1008 WP_105979268.1 PP2C family protein-serine/threonine phosphatase -
CP942_RS08775 1739931..1740332 - 402 WP_023857861.1 anti-sigma regulatory factor -
CP942_RS08780 1740335..1740700 - 366 WP_031305225.1 STAS domain-containing protein -
CP942_RS08785 1740704..1741531 - 828 WP_023857863.1 RsbT co-antagonist protein RsbRA -
CP942_RS08790 1741649..1741999 - 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CP942_RS08795 1742004..1742285 - 282 WP_006638778.1 hypothetical protein Antitoxin
CP942_RS08800 1742397..1743566 - 1170 WP_199792241.1 alanine racemase -
CP942_RS08805 1743791..1744750 - 960 WP_164468292.1 outer membrane lipoprotein carrier protein LolA -
CP942_RS08810 1745094..1745693 + 600 WP_023857867.1 rhomboid family intramembrane serine protease -
CP942_RS08815 1745690..1747174 - 1485 WP_105979270.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T85851 WP_003179128.1 NZ_CP023666:c1741999-1741649 [Bacillus paralicheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T85851 NZ_CP023666:c1741999-1741649 [Bacillus paralicheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT85851 WP_006638778.1 NZ_CP023666:c1742285-1742004 [Bacillus paralicheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT85851 NZ_CP023666:c1742285-1742004 [Bacillus paralicheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGCGAGCGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATTAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References