Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 225500..226067 Replicon chromosome
Accession NZ_CP023664
Organism Cycloclasticus sp. PY97N

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CPC19_RS01190 Protein ID WP_016390285.1
Coordinates 225500..225847 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CPC19_RS01195 Protein ID WP_015004879.1
Coordinates 225837..226067 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPC19_RS01165 220598..221122 + 525 WP_016390290.1 GspH/FimT family pseudopilin -
CPC19_RS01170 221116..221772 + 657 WP_016390289.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
CPC19_RS01175 221778..223091 + 1314 WP_016390288.1 hypothetical protein -
CPC19_RS01180 223120..225096 + 1977 WP_016390287.1 type IV pilus modification protein PilV -
CPC19_RS01185 225142..225405 - 264 WP_201765921.1 transposase -
CPC19_RS01190 225500..225847 - 348 WP_016390285.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CPC19_RS01195 225837..226067 - 231 WP_015004879.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
CPC19_RS01200 226214..226924 + 711 WP_016390284.1 transposase -
CPC19_RS01205 226968..228908 + 1941 WP_035850741.1 tetratricopeptide repeat protein -
CPC19_RS01210 228940..229236 - 297 WP_096910807.1 SelT/SelW/SelH family protein -
CPC19_RS01215 229276..230334 - 1059 WP_016390281.1 uroporphyrinogen decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin

PrlF antitoxin

(6-47)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12810.67 Da        Isoelectric Point: 8.5950

>T85847 WP_016390285.1 NZ_CP023664:c225847-225500 [Cycloclasticus sp. PY97N]
VTFKAFDVVVVPFPFTDRTTTKRRPALVLSNENTFNRKVGQSVLAMITSAKNLDWPLDTNIQDLDAAGLPSDSVVRMKLF
TLDDRLVLRKAGQLSSRDKQAAQAALQELLDVEYS

Download         Length: 348 bp

>T85847 NZ_CP023664:c225847-225500 [Cycloclasticus sp. PY97N]
GTGACCTTTAAGGCATTTGATGTCGTCGTTGTACCGTTTCCATTTACAGACCGGACAACAACAAAAAGGCGGCCAGCGTT
AGTCCTATCAAATGAAAATACATTTAATCGCAAGGTGGGGCAATCTGTGTTAGCTATGATAACTAGCGCTAAAAACTTAG
ATTGGCCACTAGATACCAATATTCAAGATTTAGATGCAGCAGGCCTACCATCGGATTCGGTAGTACGAATGAAGCTGTTC
ACATTAGACGATAGACTGGTTCTTCGTAAGGCAGGGCAATTGAGCAGCAGGGATAAACAAGCAGCTCAAGCGGCTCTTCA
AGAATTACTAGATGTTGAGTATAGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8738.95 Da        Isoelectric Point: 5.6864

>AT85847 WP_015004879.1 NZ_CP023664:c226067-225837 [Cycloclasticus sp. PY97N]
MQTATSKLTKKYQATIPEPVRKLLHLKMGDEIAFDIKKDGVHLRRARAVDIAFTQSLENTLSEWMTENDEEAYSDL

Download         Length: 231 bp

>AT85847 NZ_CP023664:c226067-225837 [Cycloclasticus sp. PY97N]
ATGCAAACAGCGACGAGTAAACTAACAAAGAAATACCAAGCAACAATACCAGAACCAGTAAGAAAGCTACTGCATTTGAA
AATGGGTGATGAAATTGCCTTTGATATAAAAAAAGACGGTGTTCACTTACGTAGAGCAAGAGCAGTAGATATAGCCTTCA
CGCAAAGCCTAGAAAACACGTTGAGCGAGTGGATGACGGAAAATGATGAAGAGGCATATAGTGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References