Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 968698..970165 Replicon chromosome
Accession NZ_CP023663
Organism Mycoplasma bovis strain Ningxia-1

Toxin (Protein)


Gene name abiEi Uniprot ID A0A2N8U3K6
Locus tag B8187_RS04140 Protein ID WP_014829995.1
Coordinates 968698..969558 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID Q934C3
Locus tag B8187_RS04145 Protein ID WP_013456322.1
Coordinates 969551..970165 (-) Length 205 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B8187_RS04475 965683..965799 + 117 Protein_778 variable surface lipoprotein -
B8187_RS04125 966310..967289 + 980 Protein_779 hypothetical protein -
B8187_RS04530 968105..968578 - 474 Protein_780 variable surface lipoprotein -
B8187_RS04140 968698..969558 - 861 WP_014829995.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
B8187_RS04145 969551..970165 - 615 WP_013456322.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
B8187_RS04150 970348..971145 + 798 WP_099620148.1 variable surface lipoprotein -
B8187_RS04155 971188..972279 - 1092 WP_099620147.1 variable surface lipoprotein -
B8187_RS04160 972462..973076 + 615 WP_013456322.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
B8187_RS04165 973069..973929 + 861 WP_014829995.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
B8187_RS04480 974049..974162 + 114 Protein_787 variable surface lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-234)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(13-59)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 33280.36 Da        Isoelectric Point: 7.7731

>T85845 WP_014829995.1 NZ_CP023663:c969558-968698 [Mycoplasma bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Download         Length: 861 bp

>T85845 NZ_CP023663:c969558-968698 [Mycoplasma bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATCAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin


Download         Length: 205 a.a.        Molecular weight: 24143.83 Da        Isoelectric Point: 9.7617

>AT85845 WP_013456322.1 NZ_CP023663:c970165-969551 [Mycoplasma bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Download         Length: 615 bp

>AT85845 NZ_CP023663:c970165-969551 [Mycoplasma bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8U3K6

Antitoxin

Source ID Structure
AlphaFold DB Q934C3

References