Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) EcnAB/-
Location 4649959..4650320 Replicon chromosome
Accession NZ_CP023662
Organism Xanthomonas citri pv. citri strain Xcc49

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag CPA10_RS21105 Protein ID WP_005914328.1
Coordinates 4649959..4650093 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag CPA10_RS21110 Protein ID WP_003486606.1
Coordinates 4650168..4650320 (-) Length 51 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPA10_RS21085 4645097..4646788 - 1692 WP_015471463.1 M20/M25/M40 family metallo-hydrolase -
CPA10_RS21090 4646980..4648014 - 1035 WP_011052671.1 MBL fold metallo-hydrolase -
CPA10_RS21095 4648053..4649342 - 1290 WP_015463705.1 tryptophan--tRNA ligase -
CPA10_RS21100 4649523..4649732 - 210 WP_003486601.1 CsbD family protein -
CPA10_RS21105 4649959..4650093 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
CPA10_RS21110 4650168..4650320 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
CPA10_RS21115 4650427..4651350 - 924 WP_005927745.1 arginase -
CPA10_RS21120 4651671..4652123 + 453 WP_003486611.1 roadblock/LC7 domain-containing protein -
CPA10_RS21125 4652187..4652546 + 360 WP_003486613.1 hypothetical protein -
CPA10_RS21130 4652643..4653560 + 918 WP_011052673.1 hypothetical protein -
CPA10_RS21135 4653557..4654099 + 543 WP_003486615.1 GTPase -
CPA10_RS21145 4654537..4655220 + 684 WP_011052674.1 dTMP kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(23-42)

Antitoxin

(23-42)


Sequences


Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T85843 WP_005914328.1 NZ_CP023662:c4650093-4649959 [Xanthomonas citri pv. citri]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T85843 NZ_CP023662:c4650093-4649959 [Xanthomonas citri pv. citri]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT85843 WP_003486606.1 NZ_CP023662:c4650320-4650168 [Xanthomonas citri pv. citri]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT85843 NZ_CP023662:c4650320-4650168 [Xanthomonas citri pv. citri]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6


Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References