Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5058158..5058825 Replicon chromosome
Accession NZ_CP023661
Organism Xanthomonas citri pv. citri strain Xcc29-1

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag COR42_RS22815 Protein ID WP_005916679.1
Coordinates 5058409..5058825 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag COR42_RS22810 Protein ID WP_005916676.1
Coordinates 5058158..5058412 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COR42_RS22785 5054280..5054499 + 220 Protein_4217 RNA 2'-phosphotransferase -
COR42_RS22790 5054656..5055921 + 1266 WP_015463799.1 cardiolipin synthase B -
COR42_RS22795 5055947..5056474 - 528 WP_005916668.1 hypothetical protein -
COR42_RS22800 5056713..5056919 + 207 WP_003489327.1 hypothetical protein -
COR42_RS22805 5056906..5058012 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
COR42_RS22810 5058158..5058412 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
COR42_RS22815 5058409..5058825 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
COR42_RS24300 5058947..5059219 - 273 WP_129545227.1 hypothetical protein -
COR42_RS24305 5059278..5059490 - 213 WP_015472901.1 hypothetical protein -
COR42_RS22820 5059747..5061366 + 1620 WP_015463800.1 hypothetical protein -
COR42_RS22825 5061470..5061868 - 399 WP_004429277.1 DUF2384 domain-containing protein -
COR42_RS22830 5062184..5062615 + 432 WP_005922907.1 hypothetical protein -
COR42_RS22835 5062644..5062970 - 327 Protein_4229 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T85839 WP_005916679.1 NZ_CP023661:5058409-5058825 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T85839 NZ_CP023661:5058409-5058825 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT85839 WP_005916676.1 NZ_CP023661:5058158-5058412 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT85839 NZ_CP023661:5058158-5058412 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References