Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 92678..93263 Replicon plasmid pApBDGP5A
Accession NZ_CP023658
Organism Acetobacter pomorum strain BDGP5

Toxin (Protein)


Gene name mazF Uniprot ID C7JIK9
Locus tag CPF11_RS13830 Protein ID WP_012813213.1
Coordinates 92934..93263 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID C7JIL0
Locus tag CPF11_RS13825 Protein ID WP_006115554.1
Coordinates 92678..92932 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPF11_RS13790 87761..88780 - 1020 WP_006115550.1 cytochrome d ubiquinol oxidase subunit II -
CPF11_RS13795 88783..90216 - 1434 WP_006115551.1 cytochrome ubiquinol oxidase subunit I -
CPF11_RS13805 90652..91611 - 960 WP_035350857.1 IS481 family transposase -
CPF11_RS13810 91669..91929 + 261 Protein_79 hypothetical protein -
CPF11_RS13815 92002..92274 + 273 WP_006115552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CPF11_RS13820 92271..92579 + 309 WP_006115553.1 PIN domain-containing protein -
CPF11_RS13825 92678..92932 + 255 WP_006115554.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CPF11_RS13830 92934..93263 + 330 WP_012813213.1 endoribonuclease MazF Toxin
CPF11_RS13835 93320..93520 + 201 WP_012813212.1 hypothetical protein -
CPF11_RS13840 93550..93870 + 321 WP_012813211.1 hypothetical protein -
CPF11_RS13845 93927..94331 - 405 WP_006115557.1 hypothetical protein -
CPF11_RS13850 94344..95159 - 816 WP_006115558.1 hypothetical protein -
CPF11_RS13855 95256..95720 - 465 WP_039891560.1 hypothetical protein -
CPF11_RS13860 95723..96571 - 849 WP_039891563.1 hypothetical protein -
CPF11_RS13865 96688..97476 - 789 WP_006115561.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..131455 131455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-107)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11925.77 Da        Isoelectric Point: 9.1225

>T85833 WP_012813213.1 NZ_CP023658:92934-93263 [Acetobacter pomorum]
MVAYVPDAGEIVWLDFSPQIGHEQAGHRPAVVLSSAAYNRIGLMLCCPLTTKLKGYPFEVAIDTDRPSAVLADQVKSFDW
RARGAKSKGRVSEVELSEIRAKARALIGR

Download         Length: 330 bp

>T85833 NZ_CP023658:92934-93263 [Acetobacter pomorum]
ATGGTTGCCTACGTACCCGATGCTGGCGAAATCGTGTGGCTCGATTTTTCACCACAAATCGGACACGAGCAGGCGGGACA
TCGACCCGCAGTCGTTTTGTCATCGGCGGCTTATAATCGGATTGGTCTGATGCTGTGTTGTCCACTGACGACCAAGCTGA
AGGGCTATCCTTTTGAAGTTGCAATCGACACTGATCGACCGAGTGCGGTGCTCGCGGATCAGGTAAAGTCTTTCGATTGG
CGGGCGCGGGGTGCGAAGAGCAAAGGGCGCGTGTCTGAGGTAGAGCTATCGGAAATTCGGGCAAAAGCCCGTGCACTGAT
AGGCAGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8921.28 Da        Isoelectric Point: 4.2550

>AT85833 WP_006115554.1 NZ_CP023658:92678-92932 [Acetobacter pomorum]
MEGAMKAVVKKWGNSASIRIPASVLAAAGLTLDQPVDVREESGRIVIEPLTVVEYDLADLLAGITPENIHPEVDFGAPVG
RELL

Download         Length: 255 bp

>AT85833 NZ_CP023658:92678-92932 [Acetobacter pomorum]
ATGGAGGGCGCAATGAAGGCTGTGGTAAAAAAATGGGGGAATAGTGCATCCATTCGTATCCCTGCTTCAGTATTGGCAGC
TGCTGGATTGACGTTGGATCAGCCAGTGGATGTGCGCGAGGAAAGCGGACGCATTGTCATTGAGCCGCTCACAGTCGTAG
AATACGATCTGGCGGATTTGTTGGCTGGGATCACCCCGGAGAATATTCATCCTGAAGTGGACTTCGGAGCGCCTGTTGGC
CGCGAACTCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1QFJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1QDC4

References