Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 688290..688873 Replicon chromosome
Accession NZ_CP023657
Organism Acetobacter pomorum strain BDGP5

Toxin (Protein)


Gene name hicA Uniprot ID F1YT37
Locus tag CPF11_RS03295 Protein ID WP_006116155.1
Coordinates 688619..688873 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID F1YT36
Locus tag CPF11_RS03290 Protein ID WP_006116153.1
Coordinates 688290..688622 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPF11_RS03275 685269..685532 - 264 WP_035353185.1 hypothetical protein -
CPF11_RS03280 685532..687640 - 2109 WP_157772569.1 transglycosylase SLT domain-containing protein -
CPF11_RS03285 687668..687982 + 315 WP_081461434.1 terminase small subunit -
CPF11_RS03290 688290..688622 - 333 WP_006116153.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CPF11_RS03295 688619..688873 - 255 WP_006116155.1 type II toxin-antitoxin system HicA family toxin Toxin
CPF11_RS03300 689113..690312 - 1200 WP_035353178.1 tyrosine-type recombinase/integrase -
CPF11_RS03305 690566..690837 + 272 Protein_653 hypothetical protein -
CPF11_RS03310 690938..691048 + 111 Protein_654 transcriptional regulator -
CPF11_RS14300 691322..691489 + 168 WP_157772570.1 hypothetical protein -
CPF11_RS14305 691907..692137 + 231 WP_139018867.1 hypothetical protein -
CPF11_RS03320 692226..692390 + 165 Protein_657 IS5/IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(56-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9479.92 Da        Isoelectric Point: 10.3861

>T85827 WP_006116155.1 NZ_CP023657:c688873-688619 [Acetobacter pomorum]
MKAKHRRTLELIFKRPVSGNVPWADIEALFVSLGAEVSEREGSRIGVFLFDEVKVFHRPHPKPDTDKGAVASVRKWLEQN
GVTP

Download         Length: 255 bp

>T85827 NZ_CP023657:c688873-688619 [Acetobacter pomorum]
ATGAAAGCCAAGCACCGCCGCACATTGGAACTGATTTTCAAGCGTCCTGTTTCGGGCAATGTGCCATGGGCAGACATTGA
AGCTTTATTTGTTTCCCTAGGGGCGGAGGTGTCTGAAAGAGAAGGCTCCCGCATAGGGGTGTTCCTGTTTGATGAGGTAA
AGGTGTTTCATAGACCTCACCCCAAACCGGATACAGACAAGGGTGCTGTAGCCTCTGTAAGAAAATGGCTTGAGCAGAAT
GGAGTGACGCCATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11992.63 Da        Isoelectric Point: 4.6742

>AT85827 WP_006116153.1 NZ_CP023657:c688622-688290 [Acetobacter pomorum]
MNNVMEIGGHRAVIQFDPEIGMFRGEFLGLNGGADFYADSVAGLQQEGETSLRVFMEMCAEKGIDPVKHYSGRFVVRLPE
DVHARAAEIAAARGISLNRLVQDVLAQVEG

Download         Length: 333 bp

>AT85827 NZ_CP023657:c688622-688290 [Acetobacter pomorum]
ATGAACAACGTAATGGAAATTGGCGGCCATCGGGCTGTTATTCAGTTTGATCCTGAAATCGGGATGTTCCGGGGTGAGTT
TCTGGGACTGAACGGAGGGGCTGATTTCTACGCAGATAGTGTGGCAGGCCTTCAGCAGGAAGGGGAAACTTCCCTCCGTG
TCTTCATGGAGATGTGTGCTGAGAAAGGCATTGATCCCGTGAAGCATTATTCAGGCCGGTTTGTTGTGAGGCTACCAGAA
GACGTTCATGCACGGGCAGCTGAGATTGCTGCAGCACGCGGGATCAGTCTTAACCGACTGGTGCAGGATGTTTTGGCACA
GGTTGAAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A401X5W6

Antitoxin

Source ID Structure
AlphaFold DB F1YT36

References