Detailed information of TA system TA085826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5146..5781
• Replicon: chromosome
• Accession: NZ_CP023657
• Organism: Acetobacter pomorum strain BDGP5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CPF11_RS00035
• Protein ID: WP_014106242.1
• Coordinates: 5371..5781 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G2I1D7
• Locus tag: CPF11_RS00030
• Protein ID: WP_010511771.1
• Coordinates: 5146..5370 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPF11_RS00005	333..1220	-	888	WP_014106237.1	LysR family transcriptional regulator	-
CPF11_RS00010	1416..2525	+	1110	WP_014106238.1	NADH:flavin oxidoreductase/NADH oxidase	-
CPF11_RS00015	2719..3375	+	657	WP_052051561.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
CPF11_RS00020	3425..4321	+	897	WP_014106240.1	NAD-dependent epimerase/dehydratase family protein	-
CPF11_RS00025	4547..4966	-	420	WP_052051562.1	hypothetical protein	-
CPF11_RS00030	5146..5370	+	225	WP_010511771.1	hypothetical protein	Antitoxin
CPF11_RS00035	5371..5781	+	411	WP_014106242.1	tRNA(fMet)-specific endonuclease VapC	Toxin
CPF11_RS00040	6444..6614	-	171	WP_075624995.1	metallothionein	-
CPF11_RS00045	6611..6961	-	351	WP_197051011.1	metalloregulator ArsR/SmtB family transcription factor	-
CPF11_RS00050	7062..8795	-	1734	WP_006115577.1	ABC transporter ATP-binding protein/permease	-
CPF11_RS00055	8792..10714	-	1923	WP_006115576.1	threonine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (9-55)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15558.79 Da
• Isoelectric Point: 6.4680

>T85826 WP_014106242.1 NZ_CP023657:5371-5781 [Acetobacter pomorum]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVRTRREVERFAARLAVLPFDSEAAAHT
ADIRAELERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTDTV

Nucleotide

• Length: 411 bp

>T85826 NZ_CP023657:5371-5781 [Acetobacter pomorum]
ATGCTGCGTTATCTGCTGGATACGAACCTCTGTATCCGGGTATTGCGGGATCGACCACAAGGGCTGCGTCCGAGGTTCAA
CAGCTGTGCGGAGGAACTCTGCATCTCGGACGTGGTTCTGTATGAGCTGCTTTATGGCGCAGAACGCTCGTCCGATCCCG
TGCGCACAAGGCGTGAAGTCGAGCGCTTCGCGGCAAGGCTGGCGGTCCTGCCATTCGACAGTGAAGCAGCCGCCCATACG
GCAGACATTCGGGCCGAACTTGAACGGAATGGCCGTATCATAGGTCCGTATGATCTCATGATTGCCGGGCATGCCCGGAG
CAGAGGGCTGATTGTTGTGACCGGCAATCTGCGGGAATTTCAGCGGGTGGAGGGTCTTCGAACCGAGGACTGGCTGACTG
ACACGGTCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8217.39 Da
• Isoelectric Point: 4.9816

>AT85826 WP_010511771.1 NZ_CP023657:5146-5370 [Acetobacter pomorum]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVRDVVIVSEGSRRIIAPADAAWDDFFAAPGVDLGERNQPAMQEREAL

Nucleotide

• Length: 225 bp

>AT85826 NZ_CP023657:5146-5370 [Acetobacter pomorum]
ATGCTGACCCGTACGACACTCTTTCTATCCAACCGCTCGCAGGCAGTGCGCCTGCCGAAGATGGTCGCCTTCGGGGAGCA
GGTGCGTGACGTCGTCATTGTGTCCGAAGGTTCACGACGCATCATCGCCCCCGCTGACGCAGCGTGGGATGATTTCTTTG
CGGCTCCCGGCGTGGATCTGGGGGAGCGGAACCAGCCGGCCATGCAGGAACGTGAGGCGCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A094ZE42