Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3703437..3704077 Replicon chromosome
Accession NZ_CP023656
Organism Halomonas hydrothermalis strain Y2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CLM76_RS17345 Protein ID WP_016913422.1
Coordinates 3703437..3703847 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8H9I372
Locus tag CLM76_RS17350 Protein ID WP_039177604.1
Coordinates 3703847..3704077 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM76_RS17325 3698595..3699674 + 1080 WP_096923191.1 isopenicillin N synthase family oxygenase -
CLM76_RS17330 3699671..3700387 + 717 WP_096923192.1 hypothetical protein -
CLM76_RS17335 3700426..3702237 + 1812 WP_096923193.1 allophanate hydrolase -
CLM76_RS17340 3702276..3703328 - 1053 WP_096923194.1 hypothetical protein -
CLM76_RS17345 3703437..3703847 - 411 WP_016913422.1 tRNA(fMet)-specific endonuclease VapC Toxin
CLM76_RS17350 3703847..3704077 - 231 WP_039177604.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CLM76_RS17355 3704297..3705976 - 1680 WP_096923195.1 2-isopropylmalate synthase -
CLM76_RS17360 3705990..3706871 - 882 WP_096923196.1 ion transporter -
CLM76_RS17365 3707120..3707875 + 756 WP_039177805.1 hypothetical protein -
CLM76_RS17370 3707938..3708882 - 945 WP_039177612.1 phosphoserine phosphatase SerB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15162.52 Da        Isoelectric Point: 7.9065

>T85825 WP_016913422.1 NZ_CP023656:c3703847-3703437 [Halomonas hydrothermalis]
MLKFMLDTNICIFTIKNRPQEVREAFKQHHGQLCISTVTLMELVYGAEKSAFPERNLATIEGFAARLDVLMYDEAAASHT
GQLRAEQAKVGKPIGPYDQMIAGHARSRGLILVTNNMREFKAVPGLRVEDWVGSGQ

Download         Length: 411 bp

>T85825 NZ_CP023656:c3703847-3703437 [Halomonas hydrothermalis]
ATGCTCAAGTTCATGCTCGATACCAATATCTGCATTTTCACGATTAAAAATCGTCCGCAAGAGGTTCGTGAGGCATTCAA
ACAGCATCATGGGCAGCTGTGCATCAGTACTGTCACACTGATGGAGTTGGTGTATGGTGCAGAAAAATCTGCTTTCCCTG
AACGTAATTTAGCCACCATCGAAGGGTTTGCAGCCAGGCTGGACGTGTTGATGTACGACGAGGCAGCGGCATCGCATACA
GGGCAGCTGCGCGCTGAACAAGCCAAGGTGGGCAAGCCCATAGGCCCTTACGATCAAATGATCGCCGGTCACGCGCGCTC
ACGAGGGCTGATACTGGTCACCAACAATATGCGCGAGTTCAAAGCAGTGCCGGGCTTGCGTGTAGAAGATTGGGTAGGCT
CGGGGCAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8432.45 Da        Isoelectric Point: 4.5358

>AT85825 WP_039177604.1 NZ_CP023656:c3704077-3703847 [Halomonas hydrothermalis]
MEQGAVFQSNRSQAVRLPKALALPEGVKRVDIVAIGRTRVISPAGEAWDSWFEGEGVSADFMSSREQPPEQERDLF

Download         Length: 231 bp

>AT85825 NZ_CP023656:c3704077-3703847 [Halomonas hydrothermalis]
ATGGAACAAGGCGCAGTCTTTCAGAGTAATCGAAGCCAGGCGGTTCGACTGCCCAAAGCGTTGGCTCTGCCAGAAGGTGT
AAAGCGAGTCGACATCGTGGCCATTGGTCGTACCCGGGTTATATCGCCAGCCGGGGAGGCCTGGGATAGCTGGTTTGAGG
GTGAAGGCGTGAGCGCTGACTTCATGTCGTCACGTGAGCAGCCTCCCGAACAGGAACGAGACCTGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References