Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2558181..2558761 Replicon chromosome
Accession NZ_CP023656
Organism Halomonas hydrothermalis strain Y2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CLM76_RS12030 Protein ID WP_096922614.1
Coordinates 2558181..2558483 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CLM76_RS12035 Protein ID WP_081195623.1
Coordinates 2558480..2558761 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM76_RS12000 2553923..2554885 + 963 WP_016914466.1 ABC transporter ATP-binding protein -
CLM76_RS12005 2554882..2555655 + 774 WP_016914465.1 ABC transporter permease -
CLM76_RS12010 2555694..2556527 + 834 WP_039181225.1 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF -
CLM76_RS12015 2556554..2557114 + 561 WP_039181222.1 nitroreductase family protein -
CLM76_RS12020 2557139..2557645 + 507 WP_096922613.1 YiiD C-terminal domain-containing protein -
CLM76_RS12030 2558181..2558483 + 303 WP_096922614.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLM76_RS12035 2558480..2558761 + 282 WP_081195623.1 putative addiction module antidote protein Antitoxin
CLM76_RS12040 2559143..2559838 + 696 WP_096922615.1 cyclase family protein -
CLM76_RS12045 2559923..2560972 + 1050 WP_096922616.1 TRAP transporter substrate-binding protein -
CLM76_RS12050 2561004..2561621 + 618 WP_096922617.1 TRAP transporter small permease -
CLM76_RS12055 2561618..2562919 + 1302 WP_096922618.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-88)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11346.94 Da        Isoelectric Point: 6.9797

>T85824 WP_096922614.1 NZ_CP023656:2558181-2558483 [Halomonas hydrothermalis]
MKIISETDTYSDWFDKLRDARARAKILARLRWAELGNFGDCEPLGEGVSELRVHYGPGYRVYFVQRGYELIILLAGGDKS
SQAKDIDIAKQLARDLKEAP

Download         Length: 303 bp

>T85824 NZ_CP023656:2558181-2558483 [Halomonas hydrothermalis]
ATGAAAATAATTAGCGAAACCGACACTTATTCGGACTGGTTCGATAAATTACGCGATGCTCGGGCCAGAGCGAAAATTCT
GGCTCGTCTGCGTTGGGCTGAGCTGGGCAACTTCGGGGATTGTGAGCCGCTGGGGGAAGGAGTCTCGGAATTGAGGGTTC
ACTACGGGCCTGGTTATCGAGTCTATTTTGTCCAGCGGGGGTATGAGCTGATTATTTTGTTGGCGGGCGGTGATAAATCC
AGCCAGGCAAAAGATATTGATATCGCGAAGCAATTGGCACGCGATTTGAAGGAGGCACCATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10017.41 Da        Isoelectric Point: 4.5972

>AT85824 WP_081195623.1 NZ_CP023656:2558480-2558761 [Halomonas hydrothermalis]
MSTLRKWDVVDHLNTEEEMVLYFEACLEEGDAALVAAALGDIARARGMAQLARDTGLTREGLYKALSADGNPSFATIMKV
TKALGFTLHAEAS

Download         Length: 282 bp

>AT85824 NZ_CP023656:2558480-2558761 [Halomonas hydrothermalis]
ATGAGCACACTGCGTAAATGGGATGTCGTTGACCACTTGAATACCGAAGAGGAAATGGTGTTGTACTTTGAAGCCTGCCT
TGAAGAGGGCGACGCTGCCCTGGTGGCGGCAGCGCTTGGCGATATTGCCCGCGCCCGTGGTATGGCACAGCTTGCTCGTG
ATACGGGGTTGACTCGCGAAGGGTTGTACAAGGCGCTTTCTGCTGATGGAAACCCAAGTTTTGCAACGATTATGAAGGTG
ACAAAAGCCTTGGGCTTTACGTTACATGCTGAAGCATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References