Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2168747..2169231 Replicon chromosome
Accession NZ_CP023645
Organism Shigella sonnei strain CFSAN030807

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag AT852_RS12060 Protein ID WP_014334020.1
Coordinates 2168941..2169231 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag AT852_RS12055 Protein ID WP_005142544.1
Coordinates 2168747..2168941 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT852_RS12015 (2163942) 2163942..2164298 - 357 WP_005140877.1 hypothetical protein -
AT852_RS12020 (2164356) 2164356..2164778 - 423 WP_001151171.1 DUF977 family protein -
AT852_RS12025 (2164794) 2164794..2165519 - 726 WP_000450631.1 DUF1627 domain-containing protein -
AT852_RS12030 (2165541) 2165541..2166287 - 747 WP_000788740.1 ATP-binding protein -
AT852_RS12035 (2166294) 2166294..2167358 - 1065 WP_001262380.1 hypothetical protein -
AT852_RS12040 (2167430) 2167430..2167855 - 426 WP_000693826.1 toxin YdaT family protein -
AT852_RS12045 (2167852) 2167852..2168115 - 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
AT852_RS12050 (2168242) 2168242..2168727 + 486 WP_053002468.1 helix-turn-helix domain-containing protein -
AT852_RS12055 (2168747) 2168747..2168941 + 195 WP_005142544.1 hypothetical protein Antitoxin
AT852_RS12060 (2168941) 2168941..2169231 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT852_RS12065 (2169511) 2169511..2169663 + 153 WP_000379558.1 DUF1391 family protein -
AT852_RS12070 (2169675) 2169675..2170040 + 366 WP_024174355.1 hypothetical protein -
AT852_RS12085 (2170943) 2170943..2172019 + 1077 Protein_2184 molybdopterin dinucleotide binding domain-containing protein -
AT852_RS12090 (2172030) 2172030..2172647 + 618 WP_000213029.1 dimethylsulfoxide reductase subunit B -
AT852_RS12095 (2172649) 2172649..2173503 + 855 WP_000526502.1 dimethyl sulfoxide reductase anchor subunit family protein -
AT852_RS12100 (2173546) 2173546..2174160 + 615 WP_000148710.1 Tat proofreading chaperone DmsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / rhs/PAAR / rhs/PAAR / sodB 2032640..2260979 228339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T85805 WP_014334020.1 NZ_CP023645:2168941-2169231 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T85805 NZ_CP023645:2168941-2169231 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT85805 WP_005142544.1 NZ_CP023645:2168747-2168941 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT85805 NZ_CP023645:2168747-2168941 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References