Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1312455..1313148 Replicon chromosome
Accession NZ_CP023641
Organism Pseudomonas mendocina strain MAE1-K

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag CO724_RS06320 Protein ID WP_003151133.1
Coordinates 1312455..1312832 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag CO724_RS06325 Protein ID WP_001172026.1
Coordinates 1312813..1313148 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO724_RS06305 1307553..1308500 + 948 WP_198402251.1 hypothetical protein -
CO724_RS06310 1308648..1311677 - 3030 WP_096825629.1 Tn3 family transposase -
CO724_RS06315 1311661..1312263 - 603 WP_010465829.1 recombinase family protein -
CO724_RS06320 1312455..1312832 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CO724_RS06325 1312813..1313148 + 336 WP_001172026.1 helix-turn-helix domain-containing protein Antitoxin
CO724_RS06330 1313163..1313497 + 335 Protein_1255 transposase -
CO724_RS06335 1313521..1313847 + 327 WP_000091614.1 hypothetical protein -
CO724_RS06340 1313844..1314224 + 381 WP_001054412.1 hypothetical protein -
CO724_RS06345 1314342..1314677 + 336 WP_096825630.1 DUF3391 domain-containing protein -
CO724_RS06350 1314724..1315638 + 915 WP_001736514.1 HD domain-containing protein -
CO724_RS06355 1316048..1316287 + 240 WP_034011918.1 ribbon-helix-helix domain-containing protein -
CO724_RS06360 1316287..1316697 + 411 WP_034011919.1 putative toxin-antitoxin system toxin component, PIN family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1297424..1320479 23055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T85797 WP_003151133.1 NZ_CP023641:1312455-1312832 [Pseudomonas mendocina]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T85797 NZ_CP023641:1312455-1312832 [Pseudomonas mendocina]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT85797 WP_001172026.1 NZ_CP023641:1312813-1313148 [Pseudomonas mendocina]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT85797 NZ_CP023641:1312813-1313148 [Pseudomonas mendocina]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References