85796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3826159..3826844 Replicon chromosome
Accession NZ_CP023640
Organism Mycobacterium tuberculosis strain TBV4952

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag CP497_RS18635 Protein ID WP_003417998.1
Coordinates 3826434..3826844 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CP497_RS18630 Protein ID WP_003912220.1
Coordinates 3826159..3826437 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP497_RS18610 3822148..3823749 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
CP497_RS18615 3823766..3824470 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
CP497_RS18620 3824588..3825154 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
CP497_RS18625 3825216..3826103 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
CP497_RS18630 3826159..3826437 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CP497_RS18635 3826434..3826844 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
CP497_RS18640 3826877..3828613 - 1737 WP_003418002.1 cholesterol oxidase -
CP497_RS18645 3828669..3829796 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
CP497_RS18650 3829816..3831405 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-118)

Antitoxin

(3-54)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T85796 WP_003417998.1 NZ_CP023640:3826434-3826844 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T85796 NZ_CP023640:3826434-3826844 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT85796 WP_003912220.1 NZ_CP023640:3826159-3826437 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT85796 NZ_CP023640:3826159-3826437 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TIR9


Antitoxin

Source ID Structure

References