Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2868089..2868798 Replicon chromosome
Accession NZ_CP023640
Organism Mycobacterium tuberculosis strain TBV4952

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag CP497_RS13935 Protein ID WP_003413164.1
Coordinates 2868089..2868502 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CP497_RS13940 Protein ID WP_003413167.1
Coordinates 2868541..2868798 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP497_RS13900 2863142..2864347 - 1206 WP_003413027.1 chorismate synthase -
CP497_RS13905 2864455..2864769 + 315 WP_009937839.1 hypothetical protein -
CP497_RS13910 2865065..2866276 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CP497_RS13920 2866403..2867062 + 660 WP_003899369.1 LppA family lipoprotein -
CP497_RS13925 2867059..2867721 + 663 WP_003899370.1 hypothetical protein -
CP497_RS13930 2867718..2867996 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
CP497_RS13935 2868089..2868502 + 414 WP_003413164.1 PIN domain nuclease Toxin
CP497_RS13940 2868541..2868798 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CP497_RS13945 2868795..2869172 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
CP497_RS13950 2869188..2869562 - 375 WP_003413177.1 hypothetical protein -
CP497_RS13955 2869662..2870057 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CP497_RS13960 2870054..2870299 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CP497_RS13970 2870710..2871129 - 420 WP_003413190.1 A24 family peptidase -
CP497_RS13975 2871141..2871950 - 810 WP_003413193.1 shikimate dehydrogenase -
CP497_RS13980 2871947..2873200 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
CP497_RS13985 2873193..2873705 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T85780 WP_003413164.1 NZ_CP023640:2868089-2868502 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T85780 NZ_CP023640:2868089-2868502 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAAATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT85780 WP_003413167.1 NZ_CP023640:2868541-2868798 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT85780 NZ_CP023640:2868541-2868798 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References