Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402164..2402693 Replicon chromosome
Accession NZ_CP023636
Organism Mycobacterium tuberculosis strain TBDM2699

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag CP493_RS11640 Protein ID WP_003411124.1
Coordinates 2402164..2402481 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag CP493_RS11645 Protein ID WP_003411127.1
Coordinates 2402478..2402693 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP493_RS11610 2397301..2398377 + 1077 WP_003411110.1 hypothetical protein -
CP493_RS11615 2398374..2398655 + 282 WP_003411112.1 hypothetical protein -
CP493_RS11620 2398691..2399764 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
CP493_RS11625 2399769..2400299 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CP493_RS11630 2400347..2401693 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
CP493_RS11640 2402164..2402481 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP493_RS11645 2402478..2402693 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
CP493_RS11650 2402948..2404006 + 1059 WP_003411129.1 hypothetical protein -
CP493_RS11655 2404136..2404492 - 357 WP_003411130.1 hypothetical protein -
CP493_RS11660 2404587..2405369 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
CP493_RS11665 2405637..2405927 - 291 WP_003900476.1 YggT family protein -
CP493_RS11670 2406089..2406745 - 657 WP_015456354.1 cell division protein SepF -
CP493_RS11675 2406811..2407587 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T85534 WP_003411124.1 NZ_CP023636:c2402481-2402164 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T85534 NZ_CP023636:c2402481-2402164 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT85534 WP_003411127.1 NZ_CP023636:c2402693-2402478 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT85534 NZ_CP023636:c2402693-2402478 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References